| 阚延婷 甘建和△ 孙蔚 冯婷婷 吴云辉 苏兰.聚乙二醇干扰素治疗对慢性乙型肝炎患者Th17/Treg的影响[J].,2016,16(13):2490-2492 |
| 聚乙二醇干扰素治疗对慢性乙型肝炎患者Th17/Treg的影响 |
| Effect of Polyethylene Glycol(peg) Interferon Therapy on Th17/Treg inPatients with Chronic Hepatitis B |
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| DOI： |
| 中文关键词: 慢性乙型病毒性肝炎 干扰素 免疫调控 Th17/Treg HBsAg阴转 |
| 英文关键词: Chronic hepatitis B viral hepatitis Interferon Immune regulation Th17 / Treg HBsAg negative change |
| 基金项目:国家" 十二五" 科技重大专项（2012ZX10002004-008） |
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| 中文摘要: |
| 目的：研究聚乙二醇干扰素抗病毒治疗对慢性乙型肝炎（CHB）患者Th17、Treg 及Th17/Treg 的影响，及Th17/Treg 与表面
抗原的关系。方法：30例HBeAg 阴性慢性乙型肝炎患者予聚乙二醇干扰素治疗，在治疗前与治疗后24 周、48 周时，检测外周血
Th17、Treg 的细胞频数及表面抗原定量，并与20 例健康人的Th17、Treg的细胞频数进行比较，分析聚乙二醇干扰素对Th17、Treg
的影响。结果：①CHB 患者的Th17 及Treg 细胞频数较健康人的高，但Th17/Treg 比例较健康人低。抗病毒治疗后24 周时，
Th17/Treg比例较治疗前升高，48 周时Th17/Treg 比例较24 周时稍降低（P>0.05)，48 周时与治疗前相比仍升高（P<0.05)。②治疗
结束时表面抗原阴转病人的Th17/Treg 比未阴转病人高。③慢乙肝病人的Th17/Treg 与表面抗原定量成负相关（r=-0.388，P<0.
05)。结论：CHB 患者体内存在着Th17/Treg 的失衡，干扰素可以调节CHB 患者的免疫功能，有望实现表面抗原阴转。 |
| 英文摘要: |
| Objective:To study the impact of polyethylene glycol (peg) interferon antiviral treatment on Th17 and Treg and Th17 /
Treg in patients with chronic hepatitisB (CHB), and investigate the relationship between Th17 / Treg and the surface antigen.Methods:30 cases of HBeAg negative chronic hepatitis B patients were treated with polyethylene glycol (peg) interferon. The level of Th17 and
Treg cells frequency and surface antigen quantity was detected before treatment and 24 weeks and 48 weeks after treatment. Another 20
cases of healthy people was selected as control. Th17 and Treg cells frequency was compared between two groups, and the effect of
polyethylene glycol (peg) interferon on Th17 and Treg was analyzed.Results:The frequency of of Th17 and Treg cells were higher in
CHB patients than that of healthy people, the proportion of Th17 / Treg was lower than those of healthy people. After 24 weeks of antiviral
treatment, the proportion of Th17 / Treg was increased, the percentage of Th17 / Treg at 48 weeks were slightly lower than at 24
weeks (P>0.05), and it was still higher at 48 weeks compared with before treatment (P < 0.05). At the end of the treatment, Thh17 / Treg
of the patient with surface antigen negative change was higher than the patients without negatively change. There was negative correlation
between Th17 / Treg and surface antigen quantitative (r =- 0.388）, P < 0.05).Conclusion:Patients with CHB presented Th17 / Treg
imbalance, and interferon treatment can adjust the immune function of patients with CHB, is expected to achieve the surface antigen negative
change. |
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