| 于希忠 尚文斌△ 赵娟 郭超 徐传翀.小檗碱抗氧化和抗炎作用用于糖尿病治疗的机制研究进展[J].,2016,16(12):2384-2386 |
| 小檗碱抗氧化和抗炎作用用于糖尿病治疗的机制研究进展 |
| Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatmentof Diabetes Mellitus |
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| DOI： |
| 中文关键词: 2型糖尿病 小檗碱 抗氧化作用 抗炎作用 |
| 英文关键词: Type 2 diabetes mellitus Berberine Antioxidation Anti-inflammatory effect |
| 基金项目:国家自然科学基金项目（81473391）；江苏省自然科学基金项目青年基金项目(BK2012455)；
江苏省高校优势学科建设工程项目(ysxk-2010) |
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| 中文摘要: |
| 研究表明氧化应激反应和慢性炎症反应是2 型糖尿病糖、脂代谢紊乱和胰岛素抵抗发生的重要病理机制。小檗碱是中药黄
连的主要有效成分之一。体内、外研究证实小檗碱可通过抗氧化和抗炎作用发挥对2 型糖尿病的治疗作用。本文就小檗碱抗氧化
和抗炎作用用于2 型糖尿病治疗的分子机制研究进展作一综述。小檗碱抗氧化和抗炎作用机制复杂，目前的研究显示小檗碱可
通过AMPK通路、MAPK 通路、Nrf2 通路和NF-资B 通路发挥抗氧化和抗炎作用。然而，小檗碱的抗氧化和抗炎作用仍需进一步的
深入研究证实。明确小檗碱的抗氧化和抗炎作用的分子机制，有助于进一步了解小檗碱治疗糖尿病作用的机理，为探寻治疗糖尿
病的天然药物提供理论依据。 |
| 英文摘要: |
| Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Recent studies
showed that Berberine had antioxidant and anti-inflammatory activities, which contributed in part to its efficacy against diabetes mellitus.
In this review, we summarized the antioxidant and anti-inflammatory activities of BBR as well as their molecular basis. The antioxidant
and anti-inflammatory activities of berberine were mediated through multiple cellular kinases and signaling pathways, such as AMP
activated protein kinase(AMPK), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid-2-related factor-2 (Nrf2) pathway,
and nuclear factor-kB (NF-kB) pathway. However, detailed mechanisms and pathways of berberine still need further investigation.
Clarification of these issues could help to understand the pharmacology of berberine in the treatment of diabetes mellitus and promote the
development of antidiabetic natural products. |
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