| 孙佳琦 张甘霖 于明薇 孙旭 王笑民△.植物雌激素与乳腺癌发病发展的研究进展[J].,2016,16(12):2368-2371 |
| 植物雌激素与乳腺癌发病发展的研究进展 |
| Research Progress of Phytoestrogen in Incidence and Developmentof Breast Cancer |
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| DOI： |
| 中文关键词: 植物雌激素 乳腺癌 雌激素受体 |
| 英文关键词: Phytoestrogen Breast cancer Estrogen receptor |
| 基金项目:北京市自然科学基金项目（7122083；7132104）；北京市科技计划项目（D131100002213001） |
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| 中文摘要: |
| 总结植物雌激素（phytoestrogen，PE）在乳腺癌发病、发展过程中的研究进展。应用Medline、Embase、CNKI及VIP数据库检
索" 植物雌激素、乳腺癌" 相关基础临床试验流行病学调查。PE 作为非甾体结构的雌激素类似物，能够与雌激素受体结合产生作
用。目前研究主要集中于PE 通过雌激素受体对乳腺癌细胞的增殖、凋亡、自噬、周期的影响和信号传导通路的研究，体外实验PE
有抑制乳腺癌细胞增殖、促进凋亡、自噬的作用，但是对转移的作用不明确，可通过PI3K/AKT 和ROS/p38MAPK途径诱导凋亡，
PE 与ER 结合或调整ER琢/ER茁达到抑制乳腺癌细胞的作用，流行病学调查未发现PE 对人体有害，鲜有临床报道。因此，本文对
PE 对乳腺癌的研究进展进行总结分析，旨在为乳腺肿瘤患者治疗提供新方向。植物雌激素有希望成为乳腺肿瘤患者治疗的新方
向。 |
| 英文摘要: |
| The research progress of phytoestrogen (PE) in the pathogenesis and development of breast cancer were Summarized.
The basic, clinical experiments and epidemiological investigation of PE and breast cancer was carried out by searching Medline,
PubMed, CNKI and VIP. As a estrogen analogues without steroidal structure, PE can combine with estrogen receptor and emits its effects
In recent years, the studies mainly focused on the effects of estrogen receptor on the proliferation, apoptosis, autophagy, and signal
transduction pathway of ER positive breast cancer. PE can inhibit the proliferation of breast cancer cells, promote apoptosis and
autophagy in vitro, but the effect on metastasis is not clear. Apoptosis can be induced by PI3K/AKT and ROS/p38MAPK pathway. PE
can inhibit breast cancer by combining with estrogen receptor or regulating the rate of ER琢/ER茁. No harmful effect is found in
epidemiological investigations. However, the clinical reports on PE treating breast cancer were rare. Therefore this article summarized the
research progress of PE to breast cancer. It aims to provide a new direction for the treatment of breast cancer. |
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