| 陈敏 吕莉 孙晓兰 殷月霞 郑建普 陆惠敏1.心肌酶和红细胞形态学参数与心肌梗死的相关性研究[J].,2016,16(12):2339-2341 |
| 心肌酶和红细胞形态学参数与心肌梗死的相关性研究 |
| The Correlation of Myocardial Enzyme and Erythrocyte MorphologyParameters with Myocardial Infarction |
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| DOI： |
| 中文关键词: 心肌梗死 心绞痛 心肌酶谱 ROC 曲线 |
| 英文关键词: Myocardial infarction Angina pectoris Myocardial enzyme spectrum ROC curve |
| 基金项目:上海市科学技术委员会科研计划项目（13ZR1437600) |
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| 中文摘要: |
| 目的：研究红细胞形态学参数对心肌梗死患者诊断作用及其与心肌酶谱的相关性。方法：选取40 例心肌梗死患者，40 例稳
定型心绞痛组患者，40 例健康对照组人群。对比分析稳定性心绞痛、急性心肌梗死(入院1h 内) 和对照组红细胞形态学参数
(MCV、MCH、MCHC、RDW)、及心肌酶谱(CK-MB、cTnI)。分析心肌梗死不同时间MCV、MCH、MCHC、RDW变化趋势。结果：稳定
性心绞痛、心肌梗死组1 h内MCV、RDW 明显高于正常对照组，差异有统计学意义(P<0.05)；稳定性心绞痛、心肌梗死组1 h内
MCHC、MCH低于对照组，差异有统计学意义(P<0.05)。心肌梗死组MCV、RDW在发病后1 h、24 h、48 h、7 d水平逐渐升高，各时
间点间差异有统计学意义(P<0.05)。心肌梗死组发病后1 h、24 h、48 h、7 d、14 d MCHC、MCH 水平逐渐降低，各时间点间差异有统
计学意义(P<0.05)。RDW和CK-MB、cTnI呈正相关性(P<0.05)。RDW对心肌梗死诊断的灵敏度最高达到93.4%，特异度为69.7%，
RDW 对急性心肌梗塞的诊断临界值为14.04%。结论：RDW对心肌梗死的诊断具有较高的敏感性，可用于临床早期诊断心肌梗
死，为临床诊断提供一新的诊断标准。 |
| 英文摘要: |
| Objective:To study the correlation of erythrocyte morphological parameters with the myocardial enzyme in patients
with myocardial infarction and its value in diagnosis.Methods:We selected 40 patients with myocardial infarction, 40 patients with
stable angina pectoris, and 40 healthy people as control group. We made contrast analysis on Erythrocyte morphology parameters (MCV,
MCH, MCHC, RDW), and myocardial enzyme spectrum (CK-MB, cTnI) between the three groups. The trends of MCV, MCH, MCHC
and RDW in myocardial infarction in different time were also analyzed, as well as their correlation with myocardial enzyme.Results:Within 1 h, the MCV and RDW levels were significantly higher in the stable angina group and myocardial infarction group than in
normal control group and the difference was statistically significant (P<0.05). The MCHC and MCH levels within 1 h were lower in the
stable angina group and myocardial infarction group than in the control group and the difference was statistically significant (P<0.05).
The levels of MCV and RDW rose gradually in myocardial infarction group from 1 h to 7 d, and differences between each time point
were statistically significant (P< 0.05). At 1 h after the onset of myocardial infarction, the levels of MCHC and MCH were gradually
reduced from1 h to 7 d, with statistical differences between each time point (P<0.05). RDWhad a positive correlation with CK-MB, cTnI
(P<0.05). It had the highest sensitivity and specificity to myocardial infarction, up to 93.4% and 69.7% respectively. RDWcritical value
to the diagnosis of acute myocardial infarction was 14.04%.Conclusion:RDWhas high sensitivity to the diagnosis ofmyocardial infarction,
and it can be used for early clinical diagnosis of myocardial infarction. It can be used as a new diagnostic criterion for clinical diagnosis. |
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