| 王骄 郑向青 罗羽慧 李晓丽 梅霞.H 型高血压患者血清Hcy、Cyst-C及UA水平变化及其在颈动脉粥样硬
化中的预测价值[J].,2016,16(12):2296-2299 |
| H 型高血压患者血清Hcy、Cyst-C及UA水平变化及其在颈动脉粥样硬
化中的预测价值 |
| H Type Hypertension：Changes of SerumHcy, Cyst-C and UA Levelsand Their Predictive Value in Carotid Atherosclerosis |
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| DOI： |
| 中文关键词: 同型半胱氨酸 尿酸 胱抑素C 高血压 动脉粥样硬化 |
| 英文关键词: Hyperhomocysteine Uric acid Cystatin C Hypertension Atherosclerosis |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：探讨H型高血压患者血清同型半胱氨酸（Hcy）、尿酸（UA）及胱抑素C（Cyst-C）水平对颈动脉粥样硬化发生的预测价
值。方法：本研究于2014 年5月~2015年5 月期间，选择我院收治确诊为H 型高血压患者163 例为研究对象，根据其颈动脉内膜
中层厚度(cIMT)的不同分为cIMT正常组（51 例）、cIMT 增厚组（54 例）和颈动脉斑块组（58 例）。检测并比较三组间性别、年龄、血
清Hcy、Cyst-C、UA、血糖(GLU)、血脂、血尿素氮（Bun）、血肌酐（Scr)水平，分析其与颈动脉cIMT 的关系，并采用logistic 回归分析
颈动脉粥样硬化的影响因素。结果：三组间HDL-C、Hcy、Cyst-C、UA 水平比较，差异均存在统计学意义（均P<0.05）；cIMT 与Hcy、
Cyst-C、UA 均呈现正相关关系（r=0.23, 0.32, 0.30; P<0.05），与HDL-C 水平呈现负相关关系（r=-0.410,P<0.05）；Logistic 回归分析
显示Hcy、Cyst-C、UA 水平是颈动脉粥样硬化危险因素（OR=1.203，6.395, 1.023；均P<0.05）。结论：H 型高血压患者血清Hcy、
Cyst-C 及UA 水平均与cIMT正相关，是导致颈动脉粥样硬化的独立危险因素，可用于临床早期预测动脉粥样硬化发生与发展。 |
| 英文摘要: |
| Objective:To explore the predictive value of serum hyperhomocysteine (Hcy), uric acid (UA) and cystatin C(Cyst-C)
levels in the occurrence of carotid atherosclerosis in patients with H type hypertension.Methods:A total of 163 patients with H type
hypertension, who were admitted to Chongqing Zhongshan Hospital from May 2014 to May 2015, were chosen as research subjects and
divided into normal carotid intima-media thickness (cIMT) group (n=51), thickened cIMT group (n=54) and carotid artery plaque group
(n=58) according to the difference of cIMT. The gender, age, serumHcy, Cyst-C, UA, blood glucose (GLU), blood lipid, blood urea
nitrogen(Bun) and serum creatinine(Scr) levels among the three groups are detected and compared, and their correlation with cIMT was
analyzed. The influencing factors of carotid atherosclerosis were analyzed by logistic regression analysis.Results:There were significant
differences in the HDL-C, Hcy, Cyst-C and UA levels among the three groups (P<0.05). cIMT was positively correlated with the serum
Hcy, Cyst-C and UA (r=0.23, 0.32, 0.30; P<0.05), negatively correlated with HDL-C (r= -0.410, P<0.05). Logistic regression analysis
showed that the levels of Hcy, Cyst-C and UA were the risk factors of carotid atherosclerosis (OR=1.203, 6.395, 1.023; P<0.05).Conclusion:Serum Hcy, Cyst-C and UA levels are positively correlated with cIMT in the patients with H type hypertension. They are the
independent risk factors leading to carotid atherosclerosis,which can be used to predict the occurrence and development of atherosclerosis
in the early stage in clinic. |
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