| 胡荣芳 刘力戈△ 李芙蓉 姜文娟 骞芳.卡托普利与坎地沙坦对老年糖尿病肾病患者肾功能的影响[J].,2016,16(12):2278-2280 |
| 卡托普利与坎地沙坦对老年糖尿病肾病患者肾功能的影响 |
| Effects of Captopril and Candesartan on the Renal Function of ElderlyPatients with Diabetic Nephropathy |
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| DOI： |
| 中文关键词: 糖尿病肾病 卡托普利 坎地沙坦 |
| 英文关键词: Captopril Candesartan Diabetic nephropathy |
| 基金项目:北京市自然科学基金项目（90720062） |
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| 中文摘要: |
| 目的：研究卡托普利联合坎地沙坦对糖尿病肾病患者肾功能的影响及临床疗效。方法：选择2014 年5 月-2015 年5 月我院
收治的糖尿病肾病患者90 例，根据治疗方法不同分为观察组和对照组。对照组给予卡托普利治疗，观察组在对照组基础上加用
坎地沙坦治疗。观察并比较两组患者的临床疗效以及治疗前后空腹血糖、血尿素氮、血肌酐、24 h尿蛋白等水平的变化情况。结
果：观察组的治疗总有效率为93.3%，对照组的治疗总有效率为84.4%；观察组患者的临床疗效显著高于对照组，但差异并不具有
统计学意义(P>0.05)。与治疗前比较，两组患者治疗后的空腹血糖、血尿素氮、血肌酐及24 h尿蛋白水平均显著降低，差异具有统
计学意义(P<0.05)；治疗后，观察组患者的空腹血糖、血尿素氮、血肌酐和24 h尿蛋白值均显著均明显低于对照组，差异均具有统
计学意义(P<0.05)。结论：卡托普利联合坎地沙坦治疗糖尿病肾病较单独采用卡托普利治疗能够更加有效的改善患者的临床症
状，保护患者的肾功能，具有较好的临床疗效。 |
| 英文摘要: |
| Objective:To study the effect of captopril combined with candesartan on the renal function of elderly patients with
diabetic nephropathy and its clinical efficacy.Methods:90 cases of elderly patients with diabetic nephropathy who were treated in our
hospital from May 2014 to May 2015 were selected and divided into the observation group and the control group according to different
treatment methods. The patients in the control group were treated with captopril, while the patients in the observation group were treated
with candesartan plus captopril. Then the clinical efficacy and the changes of blood glucose, blood urea nitrogen, serum creatinine, 24 h
urinary protein and other indicators of renal function of patients in both groups were observed and compared.Results:The total effective
rate of observation group was 93.3%, which was higher than 84.4% of the control group, but no statistically significant difference was
found between the two groups (P>0.05). Compared with before treatment, the FBG, BUN, serum creatinine and 24 h urinary protein in
both groups decreased after treatment (P<0.05). After treatment, the FBG, BUN, serum creatinine and 24 h urinary protein of patients in
the observation group were significantly lower than those of the control group (P<0.05).Conclusion:Captopril candesartan had
significant clinical effects on the improvement of renal function of patients with diabetic nephropathy, which was worthy of clinical
application. |
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