| 杨希茹 薛宁 付蓉 温卓宇 潘凯丽.儿童急性淋巴细胞白血病血清乳酸脱氢酶的临床研究[J].,2016,16(12):2271-2273 |
| 儿童急性淋巴细胞白血病血清乳酸脱氢酶的临床研究 |
| A Clinical Study on the SerumLactate Dehydrogenase Level of AcuteLymphoblastic Leukemia in Children |
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| DOI： |
| 中文关键词: 乳酸脱氢酶 急性淋巴细胞白血病 儿童 |
| 英文关键词: Serumlactate dehydrogenase Acute lymphoblastic leukemia Children |
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| 中文摘要: |
| 摘要目的：探讨儿童急性淋巴细胞白血病(ALL)患者不同时期血清LDH水平的变化及其临床意义。方法：回顾性分析我院2010
年1 月-2014 年12 月收治的90 例儿童ALL患者，并抽选同期52 例健康儿童作为对照组，采用酶法检测ALL患者初诊前、d19
诱导缓解化疗后、ALL复发时及正常对照组的LDH 值，分析LDH 与ALL 疾病进程的关系。结果：90 例ALL患者初诊组血清
LDH水平为684.70± 906.57 U/L，89 例d19化疗后组为233.83± 39.53 U/L，其中13 例ALL复发前经诱导缓解治疗d19 的LDH
水平为196.30± 54.48 U/L，13 例复发组为877.61± 1230.69 U/L，52 例对照组为202.59± 54.09 U/L，初发ALL 患者血LDH 水平
明显高于d19 化疗后组和对照组，差异有统计学意义(P<0.01)，13 例ALL复发前d19 诱导缓解后与复发时血清LDH 水平相比，
差异有统计学意义(P<0.01)。d19 诱导缓解化疗后组患儿骨髓白血病细胞数百分比与ALL 初诊组相比显著降低，差异有统计学意
义(P<0.01)。骨髓白血病细胞百分比与血清LDH水平对于评估儿童ALL预后的影响是一致的，但二者不具有直线相关关系(P＞
0.05)。结论：血清LDH 水平可有助于儿童ALL的诊断、疾病进展及预后评估。 |
| 英文摘要: |
| Objective:To investigate the clinical significance and the value of prognosis evaluation on the monitoring of serum
lactate dehydrogenase (LDH) levels in children with acute Lymphoblastic leukemia.Methods:A total of 90 children patients with ALL,
who were given chemotherapy in XiJing Hospital from January 2010 to December 2014, were chosen as ALL group, and 52 healthy
subjects, as control group. Serum lactate dehydrogenase were performed in ALL patients on admission, day 19 of induction and relapse
and healthy contral by using enzyme method.Results:LDH levels of ALL patients in different stages of the disease were diferent. The
LDH levels of incipient stages in ALL patients were 684.70 ± 906.57 U/L, which significantly higher than those of remission stage
(233.83± 39.53 U/L) in ALL patients and those in healthy controls (202.59± 54.09 U/L) (P<0.01). Besides, the LDH levels of relapse
stages were 877.61± 1230.69 U/L, which notably higher than those of day 19 of induction stage（196.30± 54.48 U/L）in 13 ALL patients.
A significant decrease of bone marrow blast cell percentages were observed at day 19 of induction fromadmission (P＜0.01), the impact
of bone marrow blast cell percentages in assessing the prognosis of childhood ALL is in accordance with serum lactate dehydrogenase.
But there was no correlation between bone marrow blast cell percentages and serumlactate dehydrogenase (P＞0.05).Conclusion:The
LDH levels can be used as a supplementary indicator of ALL diagnosis, disease progression and therapeutic effect evaluation. |
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