| 车轩 金宏波 杨永滨 米园园1 张铁民.Cajal间质细胞及其可塑性的研究进展[J].,2016,16(10):1988-1990 |
| Cajal间质细胞及其可塑性的研究进展 |
| Research Progress of the Basic Function and Plasticity of Interstitial Cellsof Cajal |
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| DOI： |
| 中文关键词: Cajal 间质细胞 胃肠动力性疾病 可塑性 |
| 英文关键词: Interstitial cells of Cajal Gastrointestinal motility disorders Plasticity |
| 基金项目:黑龙江省自然科学基金项目（D0333） |
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| 中文摘要: |
| Cajal 间质细胞(interstitial cells of Cajal，ICC)是一类主要分布于胃肠道的间质细胞，与平滑肌细胞以及肠神经细胞有着紧密
的关系。ICC分布于整个胃肠道，是胃肠道起搏细胞，具有产生和传播慢波的功能，参与神经递质调节，在一些胃肠动力性疾病中
表现为异常状态。近期，关于ICC 的生理功能、损伤和恢复机制的研究取得了显著的进展。ICC网络存在动态平衡，为了维持ICC
网络功能，ICC 周期代谢需要被紧密的控制调节平衡ICC死亡和更替。研究表明，ICC 具有高度的可塑性，在一些缺失ICC的疾
病中ICC 并不一定死亡，转分化、去分化和细胞凋亡可能是ICC 丢失的机制。。本文主要对Cajal间质细胞及其可塑性的研究进展
进行了综述。 |
| 英文摘要: |
| Interstitial cells of Cajal (ICC) are a kind of cells mainly found in the gastrointestinal tract which were closely
associated with muscular cells and enteric nerves. ICC had important functions in the control of gastrointestinal motility. They were the
pacemaker cells of gastrointestinal tract, which could generate and propagate the slow wave, also involved in the regulation of
neurotransmitter. ICC were mainly distributed in the gastrointestinal tract and were abnormal in most gastrointestinal motility disorders.
Recently, significant steps forward had been made in our understanding of the physiology of ICC as well as mechanisms of injury and
recovery. ICC numbers were dynamic to maintain functional ICC networks, ICC turnover needs to be tightly controlled with processes
that regulate both ICC loss and ICC replacement. Studies had shown that ICC have a remarkable degree of plasticity, which meant that
loss of ICC in some disorders didn't not necessarily mean death of these cells. Transdifferentiation, dedifferentiation and apoptosis had
been proposed as the mechanisms for ICC loss. Investigating the mechanism of plasticity will help to understand the pathogenesis of
gastrointestinal motility disorders. |
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