| 许宏伟 昌丽艳 刘燕 蒋丹丹 徐磊.血栓通注射液对急性脑出血患者血清IL-8、IL10 水平的影响[J].,2016,16(10):1867-1870 |
| 血栓通注射液对急性脑出血患者血清IL-8、IL10 水平的影响 |
| Effect of Thrombus Injection on the SerumLevels of IL-8, IL10, in Patientswith Acute Cerebral Hemorrhage |
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| DOI： |
| 中文关键词: 急性脑出血 血栓通注射液 白介素 血肿周围低密度 |
| 英文关键词: Acute cerebral hemorrhage Thrombus injection Interleukin Low density around the hematoma |
| 基金项目:湖南省自然科学基金项目(08JJ3036) |
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| 中文摘要: |
| 目的：探讨血栓通注射液对急性脑出血患者血清IL-8、IL10 以及与颅内血肿水平影响及临床意义。方法：选取我院收治的急
性脑出血患者80 例，随机分为对照组及实验组，对照组以常规消肿治疗，实验组在对照组基础上予以血栓通注射液活血消肿治
疗。比较各组患者治疗前后IL-8、IL-10、TNF-琢、CRP水平、颅内血肿面积、层数和低密度影像水平以及NIHSS 功能评分变化情况。
结果：与治疗前比较，两组患者IL-8、IL-10、TNF-琢、CRP 及颅内血肿水平均降低（P＜0.05）；与对照组相比较，实验组患者治疗后
IL-8、IL-10、TNF-琢、CRP 及颅内血肿水平较低（P＜0.05）；NIHSS 功能评分较高，差异具有统计学意义（P＜0.05）。结论：血栓通注
射液可改善急性脑出血患者血肿周围脑组织水肿状态及炎性反应状态，降低炎性因子及坏死因子的释放，改善病灶区脑组织血
液循环，可作为临床有效治疗方案。 |
| 英文摘要: |
| Objective:To investigate the effect of thrombus injection on the serum levels of IL-8, IL10, and intracranial hematoma
in patients with acute cerebral hemorrhage.Methods:80 patients with acute cerebral hemorrhage from our hospital were selected and
randomly divided into the control group and the experiment group. The patients in control group were given conventional treatment of
swelling and the patients in experiment group were treated on the base of the control group with thrombus injection. The serum levels of
IL-8, IL10, the area, number and low density index of intracranial hematoma and NIHSS score were compared before and after treatment.Results:Compared with before treatment, the level of IL-8, IL-10, TNF-alpha, CRP and were lower and the intracranial hematoma were
decreased（P＜0.05). Compared with the control group after treatment, the level of IL-8, IL-10, TNF-alpha and CRP were lower and the
intracranial hematoma was decreased more obviously（P＜0.05), and the NIHSS score were higher in experiment group （P＜0.05).Conclusion:Thrombus injection can improve the state of edema and inflammatory reaction, reduce the release of inflammatory factors
and necrosis factor, and has a good clinical effect in the treatment of acute cerebral hemorrhage. |
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