| 杨丽媛 孙姝 逄明杰 郭菲菲 孙向荣 公衍玲 徐珞.大鼠室旁核注射orexin-A对体重的影响[J].,2016,16(8):1450-1453 |
| 大鼠室旁核注射orexin-A对体重的影响 |
| Effect of Orexin-A Microinjected into the Paraventricular Nucleus ofHypothalamus on BodyWeight of Rats |
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| DOI： |
| 中文关键词: Orexin-A PVN 非运动性活动产热 负能量平衡 体重 |
| 英文关键词: Orexin-A PVN Non-exercise activity thermogenesis Negative energy balance Body weight |
| 基金项目:国家自然科学基金项目(81470815，31071014，81100260，81270460，81300281，81500414)；
山东省优秀中青年科学家科研奖励基金项目（BS2014YY009）；青岛市科技局项目（13-1-4-170-jch，14-2-3-3-nsh） |
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| 中文摘要: |
| 目的：探讨大鼠室旁核（PVN）注射orexin-A对体重的影响。方法：大鼠室旁核（PVN）微量注射orexin-A，用大脑置管埋管、组
织化学染色等方法探讨PVN 注射orexin-A 对其体重的影响。结果：与安慰剂组大鼠相比，PVN 注射orexin-A 组大鼠体重明显减
轻（P<0.05），而orexin-A 组和安慰剂组摄食量无明显差异(P＞0.05)。注射结束后6 天，orexin-A 处理大鼠的体重仍显著低于注射
前（P<0.05），而安慰剂组大鼠则比注射前显著增重（P<0.05）。药物注射可显著降低机体脂肪，但并不特异存在于注射orexin-A 或
安慰剂的大鼠身上。Orexin-A 组和安慰剂组大鼠的肌肉量和脂肪量均显著降低（P<0.05），但注射orexin-A 的大鼠降低更明显。与
安慰剂组相比，orexin-A 处理后的摄食转化率显著降低（P<0.05）。结论：大鼠室旁核（PVN）注射orexin-A 可通过增加活动量产生
负能量平衡，引起体重减轻。 |
| 英文摘要: |
| Objective:To investigate the effect of orexin-A microinjected into the paraventricular nucleus of the hypothalamus
(PVN) on body weight in rats.Methods:Chronic guide cannulae were implanted into PVN of rats. Orexin-A was microinjected into the
brain site. The effect of orexin-A on body weight in rats was detected.Results:The loss of body weight in orexin-A-treated rats was more
significantly than their vehicle-injected counterparts（P<0.05）, but they had no difference in food intake (P＞0.05). The rats were more
significantly active after intra-PVN orexin microinjection compared to vehicle（P<0.05）Conclusion:Orexin-A microinjected into the
paraventricular nucleus of the hypothalamus (PVN) can induce weight loss in rats through producing negative energy balance via the
increase of physical activity. |
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