李文娟 唐晓鹏 蒋芳清 蔡春琳 潘美民.Cyclin D1, Bcl-2, P53和Survivin在丙型肝炎病毒相关肝细胞肝癌中
临床病理意义[J].,2016,16(8):1439-1446 |
Cyclin D1, Bcl-2, P53和Survivin在丙型肝炎病毒相关肝细胞肝癌中
临床病理意义 |
The Clinicopathological Significance of CyclinD1, Bcl-2, P53 and Survivin in Hepatitis C virus Related Hepatocellular Carcinoma |
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DOI: |
中文关键词: 丙型肝炎病毒 肝细胞性肝癌 肿瘤发生 预后 |
英文关键词: HCV HCC Carcinogenesis Prognosis |
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中文摘要: |
目的:研究cyclin D1,bcl-2,p53 和survivin 在丙型肝炎病毒(hepatitis C virus,HCV)相关性肝细胞性肝癌(hepatocellular
carcinoma,HCC)癌组织及癌旁组织中的表达,探讨其表达与丙型肝炎病毒相关性肝细胞性肝癌患者临床病理特征及生存预后之
间的关系。方法:采用免疫组化检测方法检测cyclin D1,bcl-2,p53 和survivin 在丙型肝炎病毒相关性肝癌组织、癌旁组织和基本
正常的肝组织中的表达,统计分析各因子的表达情况以及与患者临床病理特征的关系,并利用Kaplan-Meier 分析法进一步分析
各因子与患者生存预后之间的关系。结果:cyclin D1,bcl-2,p53 和survivin 在基本正常肝脏组织、癌旁组织和癌组织中的表达呈现
递增的趋势,且cyclin D1,bcl-2,p53 和survivin 在癌组织的表达显著高于癌旁组织和基本正常的肝脏组织(P<0.05);经统计学分
析,cyclin D1,bcl-2 和p53 与肿瘤的分化程度相关(P<0.05),而survivin 与血管的浸润情况相关(P<0.05);Kaplan-Meier 分析显示,
cyclin D1,p53 和survivin 与患者的不良预后有关(P<0.05),而bcl-2 与患者的不良预后无关(P>0.05)。结论:cyclin D1,bcl-2,p53
和survivin 可能与丙型肝炎病毒相关性肝细胞性肝癌的发生存在一定的联系,除此之外,cyclin D1,p53 和survivin 与丙型肝炎病
毒相关性肝细胞性肝癌患者的不良预后相关,而bcl-2 与预后不存在显著相关性。 |
英文摘要: |
Objective:To observe the expression of cyclin D1, bcl-2, p53 and survivin in hepatitis C virus (HCV) relative
hepatocellular carcinoma (HCC) tissue, paracarcinoma tissue and normal liver tissue, and analyze the relationship between the expression
of the 4 proteins with the clinicopathological features, tumorigenesis and prognosis of those patients.Methods:The expression of cyclin
D1, bcl-2, p53 and survivin in cancerous tissue, paracancerous tissue and normal liver tissue was detected by immunohistochemistry and
compared. The relationship between the expression of these four proteins and the clinicopathological features of patients was analyzed by
statistical software. At last, Kaplan-Meier analysis was used to analyze the correlation between the expression of those proteins and the
prognosis of HCV relative HCC patients.Results:cyclin D1, bcl-2, p53 and survivin showed an increasing trend in turn in normal liver
tissue, paracarcer tissue, cancerous tissue, and the difference between cancerous tissue and paracancerous tissue or normal liver tissue
was statistically significant(P<0.05). According to statistical analysis, the expression level of cyclin D1, bcl-2 and p53 correlated with
tumor differentiation(P<0.05)and survivin expression level correlated with vascular invasion(P<0.05). Kaplan-Meier analysis indicated
that cyclin D1, p53 and survivin had relationship with poor prognosis of HCV related HCC patients(P<0.05), however, there was no
statistically significant relationship between bcl-2 expression and prognosis of HCV related HCC patients(P>0.05).Conclusion:cyclin
D1,bcl-2,p53and survivin may play some important roles in the tumorigenesis of HCV related HCC. Moreover, cyclin D1, p53 and
survivin have a correlation with poor prognosis of HCV related HCC patients, however, bcl-2 shows no significant correlation with
prognosis of this disease. |
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