| 刘贤 何帮顺 林康 陈杰 彭红新 王书奎.幽门螺杆菌基因分型与胃病关系研究进展[J].,2016,16(7):1390-1393 |
| 幽门螺杆菌基因分型与胃病关系研究进展 |
| Research Progression on Association of Helicobactert pylori Genotypewith Stomach Disease |
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| DOI： |
| 中文关键词: 幽门螺杆菌 基因分型 Cag-PAI VacA |
| 英文关键词: Genotyping Cag-PAI VacA |
| 基金项目:国家自然科学基金项目（81172141） |
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| 中文摘要: |
| 幽门螺旋杆菌（ , Hp）已被国际癌症组织确认为胃部疾病最主要的致病因子。近年来对于Hp 菌株的基因
分型、流行病学和致病性等方面的研究逐步深入，越来越多的研究成果证实对Hp 基因分型进行细化可为精准医疗提供依据。Hp
可依照CagA 羧基末端磷酸化位点、VacA 信号区（s）中间区（m）过渡区（i）缺失区（d）和粘附因子（OMPs）进行基因分型。Hp 基因
型差异可导致不同毒性作用，从而引起不同临床结果和疗效预后。因此对Hp 基因分型可为胃病的防治提供重要依据。本文就Hp
基因分型方法、基因分型及其与胃部疾病研究进展进行如下综述。 |
| 英文摘要: |
| (Hp) has been recognized as the main pathogenic factor for stomach diseases by the international
organization for cancer. In recent years, more and more studies confirmed that the evidence for Precision Medical can be provided with
gradual deepening study on Hp genotype and epidemiology as well as pathogenesis. Hp can be genotyped by CagA carboxyl terminal
phosphorylation sites, VacA signal area (s), middle area (m) intermediate area (I) and adhesion factor (OMPs). The difference of Hp
genotype can cause different toxic effects, which lead to different clinical outcome, curative effect and prognosis. So Hp genotyping can
provide important basis for prevention and treatment of gastric disease. Hence, we performed this study to comprehensively review the
progression in method and genotyping of Hp, and association between its genotype and stomach diseases. |
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