| 李季 邹波峰 王远鹤 阮有民 刘恒.姜黄素对晚期宫颈癌患者Bcl-xL、Bcl-2、EphA2及EphrinA1表达的影响[J].,2016,16(7):1314-1317 |
| 姜黄素对晚期宫颈癌患者Bcl-xL、Bcl-2、EphA2及EphrinA1表达的影响 |
| Effects of Curcumin on EphrinA1, Bcl-2, EphA2 and Bcl-xL in Patients withAdvaned Cervical Cancer |
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| DOI： |
| 中文关键词: 晚期宫颈癌 放疗 姜黄素 基因表达 |
| 英文关键词: Advanced cervical cancer Radiotherapy Curcumin Gene expression |
| 基金项目:辽宁省科技厅自然科学基金资助项目(20032111) |
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| 中文摘要: |
| 目的：探究姜黄素对宫颈癌晚期放疗患者Bcl-xL、Bcl-2、EphA2 与EphrinA1 表达的影响。方法：收集160 例晚期宫颈癌放疗
患者的宫颈癌石蜡标本，分为姜黄素组与对照组，均给予放射治疗，姜黄素组放疗期间加服姜黄素片剂，采用免疫组化等实验方
法，观察两组病例标本Bcl-xL、Bcl-2、EphA2 与EphrinA1 的表达情况，比较两组病理标本化疗前后的凋亡细胞指数(AI)与微血管
密度(MVD)。结果：姜黄素组的Bcl-xL、Bcl-2、EphA2 与EphrinA1 的表达阳性率分别为8.3 %、43.33 %、46.67 %、15.0 %，均显著低
于对照组(P<0.05)；放疗后姜黄素组的AI 显著高于对照组(P<0.05)，MVD 显著低于对照组(P<0.05)。结论：姜黄素可抑制Bcl-xL、
Bcl-2 的表达以促进肿瘤细胞凋亡，同时降低EphA2 与EphrinA1 的表达以减少肿瘤微血管形成，有显著的抗肿瘤与放疗增敏作
用。 |
| 英文摘要: |
| Objective:To investigate the effect of curcumin on the expression of EphrinA1, EphA2, Bcl-2 and Bcl-xL in patients
with cervical cancer in advanced stage.Methods:The paraffin specimens of 160 cases of advanced cervical carcinoma treated with radiotherapy
were collected and divided into curcumin group and control group. The two groups were treated with radiotherapy, while the
curcumin group was treated with curcuminand. The expression of EphrinA1, EphA2, Bcl-2 and Bcl-xL were observed in the two groups
through the experimental method. The apoptotic cell index (AI) and microvessel density (MVD) were compared between the two groups.Results:The positive rate of EphrinA1, EphA2, Bcl-2 and Bcl-xL was 8.3 %, 43.33 %, 15 %, 46.67 %, 8.3 %, respectively, significantly
lower than that in the control group (P<0.05), respectively. AI was significantly higher than that in the control group (P<0.05), and MVD
was significantly lower than that in the control group (P<0.05).Conclusion:Curcumin can inhibit the expression of Bcl-xL and Bcl-2 in
order to promote tumor cell apoptosis, and decrease the expression of EphA2 and EphrinA1 in order to reduce tumor angiogenesis, and
has a significant effect on antitumor and radiotherapy. |
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