| 时素琴 张新林 谢峻 王涟 张静梅 李锡明 徐伟 徐标.一组有或无基因突变的特发性扩张型心肌病患者临床发病及预后的分析[J].,2016,16(7):1262-1265 |
| 一组有或无基因突变的特发性扩张型心肌病患者临床发病及预后的分析 |
| Analysis of Clinical Onset and Prognosis in Patients with Idiopathic DilatedCardiomyopathy with or without Gene Mutations |
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| DOI： |
| 中文关键词: 特发性扩张型心肌病 基因突变 临床特征 预后 相关性 |
| 英文关键词: Idiopathic dilated cardiomyopathy Mutation Clinical characteristics Prognosis Association |
| 基金项目:国家自然科学基金项目（81270281，81200148） |
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| 中文摘要: |
| 目的：分析携带基因突变和未携带基因突变的特发性扩张型心肌病（IDCM）患者的临床发病及预后的差异性。方法：收集
2011 年01 月-2014年09月于南京鼓楼医院就诊的IDCM患者115 例，经靶向二代测序鉴定后分为基因突变组和未突变组，出
院后对两组患者进行定期随访，将两组患者的临床资料及随访结果进行统计学分析。结果：两组患者的一般临床特征（如性别比
例、首发症状年龄、血压、糖尿病比例等）无显著差异（P>0.05）；辅助检查特征（如左室射血分数、左室舒张末内径、室壁厚度、
QRS-T 夹角和血肌酐水平等）无显著差异（P>0.05）；治疗情况（如药物和器械治疗）无差异（P>0.05）；随访资料（如再入院和生存分
析）亦无统计学差异（P>0.05，Log rank P = 0.12）；将性别比例、是否吸烟、是否合并糖尿病、是否植入器械、是否发生突变等临床参
数进行Cox 回归分析，发现上述参数未影响患者的临床预后（P>0.05）。结论：本组资料显示携带基因突变的IDCM患者临床发病
及预后较未携带突变者无显著差异。 |
| 英文摘要: |
| Objective:Analyze the difference of clinical onset and prognosis in patients with idiopathic dilated cardiomyopathy
with or without gene mutations.Methods:A total of 115 IDCMpatients were enrolled fromJanuary 2011 to September 2014. All patients
were subjected to targeted next-generation sequencing to identify whether a pathological mutation existed. These IDCMpatients were divided
into 2 groups: the mutant group and non-mutant group. All patients were followed up with telephone contact. The clinical data and
end points were compared.Results:Comparisons between these two groups showed no significant difference in baseline characteristics
such as gender, age of symptom onset, blood pressure, and diabetes; assistant examination data such as left ventricular ejection fraction
(LVEF), left ventricular diastolic diameters (LVDD), QRS-T angles and serum creatinine level; pharmacotherapy and device implantation;
and prognosis including re-hospitalization and all-cause mortality. Factors, such as gender, smoking, diabetes, device implantation
and mutation, were analyzed by the method of Cox Regression Analysis. It showed that these factors did not influence their prognosis.Conclusion:There is no significant difference in clinical data and end points between the two groups. |
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