| 李绪东 宋纯 杨帅 高建华 于红丽.新城疫病毒抗肿瘤作用的研究进展[J].,2016,16(5):979-981 |
| 新城疫病毒抗肿瘤作用的研究进展 |
| Progress on the Antitumor Effect of Newcastle Disease Virus |
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| DOI： |
| 中文关键词: 新城疫病毒 恶性肿瘤 生物学治疗 |
| 英文关键词: Newcastle disease virus Tumor Biological treatment |
| 基金项目:国家自然科学基金项目(30973188) |
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| 中文摘要: |
| 新城疫病毒(newcastle disease virus，NDV)属副黏病毒，由于其安全性，自从被发现以来，即受到广大研究者们的关注。经过
多年的研究，新城疫病毒在抑制人肝癌、恶性胸膜间皮瘤、纤维肉瘤以及头颈癌细胞方面都取得了可喜的成果。目前，新城疫病毒
抑瘤作用的机制尚未完全阐明，研究表明主要涉及诱导肿瘤细胞凋亡，发挥抑瘤佐剂作用，增强免疫细胞活性及抑制肿瘤化疗耐
药。NDV 即使在缺氧环境下，也可以稳定的发挥抗肿瘤作用，且其强毒株具有高效的抗肿瘤作用。本文主要就近年来新城疫病毒
抗肿瘤作用的研究进展进行了综述。 |
| 英文摘要: |
| NDV (Newcastle disease virus) is paramyxovirus,due to the safety in the treatment of process, attracted many
researchers attention since its discovery. After years of development, Newcastle disease virus can suppress human hepatoma, malignant
pleural mesothelioma, fibrosarcoma, and head and neck cancer and the anti-tumor effect of NDV had been proven. The effects and
mechanisms in inhibiting tumor of Newcastle disease virus is not completely understood, possible mechanism of action is inducing
apoptosis of tumor and enhancing immune cellular activity and suppressing chemotherapy-resistant cells. NDV can exert anti-tumor
effect steady in hypoxic conditions,and virulent strain of NDV can exert highly efficient anti-tumor effects. This article reviews the recent
progress of the anti-tumor effect of Newcastle disease virus. |
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