| 赵世华 肖秀斌 仲凯励 鲁云 达永 苏航 张伟京.120 例初治、年轻、中高/ 高危弥漫大B细胞淋巴瘤的临床分析[J].,2016,16(4):682-687 |
| 120 例初治、年轻、中高/ 高危弥漫大B细胞淋巴瘤的临床分析 |
| Clinical Analysis of 120 Cases of Newly Diagnosed Young Patients withMedium/high Risk Diffuse Large B-cell Lymphoma |
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| DOI： |
| 中文关键词: 弥漫性大B 细胞淋巴瘤 预后 影响因素 无进展生存期 总生存期 |
| 英文关键词: Diffuse large B cell lymphoma Prognosis Influencing factor Progression free survival Overall survival |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨初治、年轻、中高/ 高危弥漫大B 细胞淋巴瘤(diffuse large B cell lymphoma，DLBCL)的临床特征、治疗措施及预后
影响因素。方法：回顾性分析2006 年1 月至2014 年5 月军事医学科学院附属医院淋巴瘤科收治的年龄≤ 60 岁、年龄调整的国际
预后指数(aaIPI)评分≥ 2 分的初治DLBCL病例，进行疗效及预后相关因素的分析。结果：共收集到资料完整的DLBCL 病例120
例，中位随访28(4-106)个月，3 年PFS率53.25%，OS 率61.52%。单因素分析结果显示B 症状、治疗方案及近期疗效、自体移植对
无进展生存(PFS)及总体生存(OS)率的影响有统计学意义。多因素分析结果显示治疗方案、自体造血干细胞移植是影响PFS、OS
率的独立影响因素。结论：年轻、中高/高危DLBCL具有高度异质性，病理细胞来源、Ki-67 等在本组病例中未见显著预后意义，
有待临床进一步探索。 |
| 英文摘要: |
| Objective:To analyze the clinical characteristics, treatment and influencing factors of prognosis of newly diagnosed
young patients with medium/high risk diffuse large B cell lymphoma (DLBCL).Methods:The clinical data of young (≤ 60years)
age-adjusted international Prognostic Index (aaIPI) score of 2 or 3 patients with DLBCL were collected. These patients were initially
diagnosed and treated in Academy of Military Medical Sciences from January 2006 to May 2014. The efficacy and influencing factors of
prognosis were evaluated.Results:A total of 120 DLBCL patients were included in this retrospective analysis. After a median follow-up
of 28 months, the estimated progression-free survival (PFS) and overall survival (OS) at three years were 53.25% and 61.52%. In
univariate analysis, B symptoms, regimen and therapeutic effect, ASCT had significant influence on PFS and OS. In multivariate analysis,
regimen and therapeutic effect and ASCT were independent risk factors associated with PFS, OS.Conclusion:Young patients with
medium/high risk diffuse large B cell lymphoma is a heterogeneous entity, immunological subtypes and Ki-67 index were not related to
survival, but this result is not conclusive until these factors are further tested. |
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