| 张广良 方岩 马进 谢小萍 常耀明 暴军香.四周尾部悬吊致大鼠立位耐力不良[J].,2016,16(2):242-246 |
| 四周尾部悬吊致大鼠立位耐力不良 |
| Four-weeks' Tail Suspension Causes Orthostatic Intolerance in Rats |
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| DOI： |
| 中文关键词: 模拟失重 大鼠 立位耐力不良 血压 心率 |
| 英文关键词: Simulated weightlessness Rat Orthostatic intolerance Blood pressure Heart rate |
| 基金项目:国家自然科学基金项目（81171871, 31071045, 81401550） |
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| 中文摘要: |
| 目的：观察中期(4 周)尾部悬吊大鼠在立位应激下的心血管反应。方法：采用本实验室改进的尾部悬吊方法，利用头高位倾斜
和下体负压模拟立位应激，通过股动脉插管和心电图记录检测大鼠血压和心率改变。结果：与对照组相比，4 周尾部悬吊(SUS)大
鼠体重下降及后肢承重骨骼肌萎缩；其静息血压和心率与对照组(CON)相比无明显差别(P>0.05)；在两组大鼠中，头高位倾斜和下
体负压均可导致血压降低和心率加快，但SUS大鼠平均动脉压下降幅度与CON 大鼠相比显著增大(P<0.05)，而两组的心率增快
幅度并无明显差别(P>0.05)。结论：4 周尾部悬吊大鼠在立位应激下维持血压稳定的能力减弱，可用于中期失重/模拟失重后立位
耐力不良机理的研究。 |
| 英文摘要: |
| Objective:To examine the cardiovascular response to orthostatic stress of 4 wk tail suspended rat.Methods:A
modified tail suspension method was used and the mean arterial blood pressure (MAP) and heart rate (HR) upon head-up tilt (HUT) or
lower body negative pressure (LBNP) were recorded.Results:Compared to the control rats(CON), 4 wk tail suspended (SUS) rats had no
difference in MAP or HR on rest. Both HUT and LBNP could reduce MAP and enhance HR in both groups of rat. But the magnitude of
MAP change was significantly larger in SUS rats relative to that in CON rats while the change of HR showed no significant difference
between the two groups.Conclusion:The ability to keep MAP stable upon orthostatic stress was compromised in 4 wk SUS rats and the
animal model with mid-termtreatment was suited for the research on mechanisms of orthostatic intolerance following weightlessness. |
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