| 赵晶 林泳 聂玉强 王红 王家骥.MTMR3基因1670C>T多态性与胃癌易感性的关系研究[J].,2016,16(2):221-224 |
| MTMR3基因1670C>T多态性与胃癌易感性的关系研究 |
| Polymorphismof 1670C>T in MTMR3 is Associated with the Susceptibilityto Gastric Cancer |
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| DOI： |
| 中文关键词: 胃癌 单核苷酸多态性 MTMR3 微小RNA |
| 英文关键词: Gastric Cancer Single Nucleotide Polymorphism MTMR3 MicroRNA |
| 基金项目:国家自然科学基金项目（81302078） |
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| 中文摘要: |
| 目的：探讨MTMR3基因3' 非翻译区（3'UTR）1670C>T 多态性与胃癌发病的关联。方法：通过病例对照研究，采用聚合酶
链式反应- 限制性片段长度多态性方法检测500 例胃癌患者和502 例正常对照者MTMR3 基因1670C>T 位点的基因型，通过非
条件Logistic 回归，并校正了性别、年龄、吸烟、饮酒的影响，分析该位点与胃癌易感性的关系。结果：MTMR3基因1670C>T基因
型分布在病例组和对照组均符合Hardy-Weinberg 平衡（P＞0.05）。经过年龄、性别、吸烟和饮酒状况校正的非条件logistic 回归分
析发现，与CC 基因型患者相比，含有T 等位基因的基因型（CT 和TT）患者胃癌的发病风险增高（校正优势比=1.72, 95% 置信区
间=1.36~2.16, P=3.99× 10-5）。结论：MTMR3 基因1670C>T 多态性位点与胃癌发病存在显著性关联，1670T可能是胃癌发生的一
个遗传危险因素。 |
| 英文摘要: |
| Objective:To investigate the relationship between the polymorphism of 1670C>T in 3'-untranslated region (3'UTR) of
MTMR3 and gastric cancer (GC).Methods:A case-control study was conducted. The genotypes of 1670C>T in MTMR3 were identified
with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 GC cases and 502 cancer-free controls.
Unconditional logistic regression, adjusted by gender, age, smoking and alcohol status, was used to analyze the association of genotypes
with GC risk.Results:The genotypes of 1670C>T in MTMR3 were in Hardy-Weinberg equilibriumin both controls and cases group(P＞
0.05). After adjustment for age, gender, smoking status and alcohol consumption by logistic regression, the carriers of T allele genotypes
(CT and TT) of MTMR3 were associated with a significantly increased risk of GC (adjusted OR=1.72, 95%CI=1.36-2.16, P=3.99× 10-5),
Compared with the CC wild type genotype carriers.Conclusion:The polymorphismof 1670C>T in MTMR3 is associated with GC, thus
the 1670T allele may be an inherited risk factor for GC development. |
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