| 沈炜 俞士尤 邵正才 周俊东 陈旭权.新辅助化疗与营养支持对老年结肠癌患者T 细胞，COX-2 及tM2-PK水平的影响[J].,2015,15(36):7135-7138 |
| 新辅助化疗与营养支持对老年结肠癌患者T 细胞，COX-2 及tM2-PK水平的影响 |
| Effect of Neoadjuvant Chemotherapy and Nutritional Support on the SerumTumor Markers, COX-2 and Quality of Life in Elderly Colon Cancer Patients |
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| DOI： |
| 中文关键词: 新辅助化疗 营养支持治疗 结肠癌 COX 老年患者 |
| 英文关键词: Neoadjuvant chemotherapy Nutritional support therapy Colon cancer COX Elderly patients |
| 基金项目:国家医学教育发展中心医学研究课题（2011-45-03-061） |
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| 中文摘要: |
| 目的：探讨新辅助化疗与营养支持综合治疗对老年结肠癌患者血清肿瘤标记物水平、COX-2 及生活质量影响及临床意义。
方法：选取我科收治的老年结肠癌患者80 例，根据治疗方案不同分为对照组与试验组。对照组常规行结肠癌根治切除术，试验组
应用FOLFOX3 方案。比较两组患者血清肿瘤标记物CEA 及CA19-9 水平、COX-2 水平及CD4+、CD8+及tM2-PK 水平。结果：与
治疗前相比，治疗后试验组和对照组CEA 及CA19-9 水平降低（P<0.05)，COX-2、tM2-PK 水平降低（P<0.05)，CD4+及CD4+/CD8+
水平降低（P<0.05)，CD8+水平升高（P<0.05)。与对照组比较，试验组COX-2、tM2-PK 水平、CD4+、CD8+水平改善明显优于对照组，
差异具有统计学意义（P<0.05)，而CEA 及CA19-9 水平组间比较，差异无统计学意义（P>0.05）。结论：新辅助化疗与营养支持综合
治疗可杀伤老年结肠癌患者全身不可见转移肿瘤细胞，控制病情，临床疗效理想。 |
| 英文摘要: |
| Objective:To investigate the effect of neoadjuvant chemotherapy and nutritional support on the serum tumor markers,
COX-2 and quality of life in elderly colon cancer patients.Methods:80 elderly colon cancer patients from the department of anus and
intestine surgery in our hospital were selected and divided into the control group and the experiment group by different treatment. The
control group were treated by radical resection of colon cancer. The experiment group were treated by FOLFOX3 plan. The level of CEA,
CA19-9 COX-2, CD4+, CD8+ and tM2-PK were detected and compared between two groups.Results:Compared with before treatment,
the level of CEA, CA19-9, TM2-PK, COX-2, CD4+ and CD4+/CD8+ were lower in both two groups after treatment and CD8+ level were
higher with statistical significance (P<0.05). Compared with the control group, the improvement of all these indexes except for CEA and
CA19-9 was more obviously in experimental group with statistical significance compared with control group (P<0.05).Conclusion:New
adjuvant chemotherapy and nutritional support can kill the tumor cells and control the disease in the treatment of elderly patients with
colon cancer. |
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