| 姜涛 何雅静 赵婷婷 张翼飞 张亚.BMP-7 在子痫前期肾脏损伤中的表达及临床意义[J].,2015,15(36):7091-7093 |
| BMP-7 在子痫前期肾脏损伤中的表达及临床意义 |
| Expression and Significance of BMP - 7 in Preeclampsia Renal Damage |
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| DOI： |
| 中文关键词: BMP-7 子痫前期 肾脏损伤 |
| 英文关键词: BMP - 7 Preeclampsia Renal damage |
| 基金项目:国家自然科学基金项目（81202063） |
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| 中文摘要: |
| 目的：探究BMP-7 在子痫前期肾脏损伤中的表达及临床意义。方法：选取2012 年3 月到2013 年12 月我院妇产科收治的98
例子痫前期肾脏损伤患者作为研究对象，以30例健康孕妇为对照，分别采用ELISA 方法检测血液、尿液中BMP-7 蛋白、尿茁2微
球蛋白（beta2-MG）浓度，以苄索氯胺比浊法测定24 h尿蛋白定量。结果：①与对照组相比，子痫前期肾脏损伤患者尿液及血清
BMP-7 蛋白浓度显著降低(P<0.05)；②随着病程进展，子痫前期组尿液血清BMP-7 蛋白浓度、尿白蛋白定量、beta2-MG 显著升高
(P<0.05)；③子痫前期组尿液、血清BMP-7 蛋白浓度分别与尿白蛋白定量、beta2-MG 成正相关（P＜0.05）。结论：子痫前期肾脏损伤
患者血清BMP-7 蛋白水平显著降低，可用于评估子痫前期肾脏损伤进展，对临床具有指导意义。 |
| 英文摘要: |
| Objective:To explore the expression and clinical significance of BMP - 7 in preeclampsia kidney damage.Methods:98 cases of patients with preeclampsia kidney damage from obstetrics and gynecology department from March 2012 to December 2013
were selected as the research object, and another 30 cases of healthy pregnant women was considered as controls. The concentration of
serum and urine BMP - 7 protein and beta 2 microglobulin (beta2-MG) in urine was detected by ELISA, 24 h urine protein quantitative
determination was performed with benzyl cable chloramine turbidimetry.Results:① Compared with control group, the concentration of
urine and serumBMP 7 protein in the preeclampsia group was decreased significantly (P < 0.05); ②With the progression of disease, the
concentration of urine and serum BMP 7 protein, the quantity of urine albumin of beta2-MG was significantly increased in preeclampsia
group (P < 0.05);③the concentration of urine and serumBMP 7 protein in preeclampsia group was respectively positively correlated with
quantity of urinary albumin and beta2-MG (P < 0.05).Conclusion:The serum BMP 7 protein is significantly reduced in the patients with
preeclampsia renal damage, which can be used to evaluate the progress of preeclampsia renal damage, and provide guidance for clinic. |
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