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目的：通过观察脑脊液分流术在64 例脑肿瘤患者中的临床应用效果，探讨其临床应用的价值。方法：收集2009 年1 月 -2010 年3 月我院64 例脑肿瘤患者病例资料，其临床诊断均有颅内高压，对照组32例患者给予常规手术进行肿瘤切除；观察组在对照组的基础上给予脑脊液分流术，比较两组治疗效果。结果：治疗后两组颅内压均降低，观察组降低更为明显（P<0.05）。对照组完全缓解率为15.6 %，部分缓解率为21.8 %，病程稳定率为31.3 %，病程进展率为31.3 %。观察组分别为28.1 %、31.3 %、25 % 和15.6 %。观察组完全缓解率和部分缓解率明显高于对照组（P<0.05.），病程进展率对照组明显高于观察组（P<0.05）。对照组术后两年内复发5 例，生存超过三年的17 例，生存超过五年的12 例。观察组术后两年内复发的2 例，生存超过三年的20 例，生存超过5 年的15 例。和对照组比较，观察组术后病情复发率更低，生存指数更高，比较有明显差异（P<0.05）。结论：脑脊液分流术在伴颅内高压或脑积水的脑肿瘤手术中的使用效果显著，后期的手术成功率和患者生存率提高，临床上可予以更为深入的探索。

英文摘要:

Objective:To observe the curative effects of cerebrospinal fluid shunt therapy in 64 patients with brain tumor operation, and discuss the application value in brain tumor surgery.Methods:64 cases of patients clinically diagnosed as brain tumor combining with intracranial pressure by skull CT or MRI diagnosis were collected from January 2009- march 2010 in our hospital. 32 patients in control group were given routine surgical treatment, using gamma knife, radiotherapy and biological immune therapy, tumor resection, and 32 patients in observation group were not only given the basis treatment as control group, but given cerebrospinal fluid separation surgery treatment. The therapeutic effect in the two groups was analyzed and compared.Results:The intracranial pressure of two groups were decreased after treatment, and the observation group were lower than that of the control group (P<0.05). The complete remission rate, the partial remission rate, the rate of stability, and the progression rate was repetitively 15.6 %, 21.8 %, 31.3%and 31.3 % in control group while it was 28.1 %, 31.3 %, 25 %, 15.6 %in observation group. The complete remission rate and partial remission rate in observation group was significantly higher than that of the control group (P<0.05), and the rate of progression in the control group was significantly higher than that of the observation group (P<0.05). In control group, there were 5 cases of postoperative recurrence within 2 years, 17 cases of survival more than three years, 12 cases of survival more than five years; and in observation group there were 2 cases of postoperative recurrence within 2 years, 20 cases of survival more than three years, 15 cases of survival more than 5 years. Compared with control group, the postoperative disease recurrence rate was lower in the observation group and the survival index was higher, showing obvious statistical difference (P<0.05).Conclusion:The effect of cerebrospinal fluid shunt in brain tumor surgery is remarkable, and the postoperative successful rate and survival rate can be improved, so its clinical application can be further explored.

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