| 刁宗礼 刘莎 郭王 刘旭 刘文虎.慢性肾脏病继发性甲状旁腺功能亢进的发病机制研究进展[J].,2015,15(31):6186-6189 |
| 慢性肾脏病继发性甲状旁腺功能亢进的发病机制研究进展 |
| Progress of Pathogenesis of Secondary Hyperparathyroidismin ChronicKidney Disease |
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| DOI： |
| 中文关键词: 慢性肾脏病 继发性甲状旁腺功能亢进 发病机制 |
| 英文关键词: Chronic Kidney Disease Secondary hyperparathyroidism Pathogenesis |
| 基金项目:国家自然科学基金项目（81300607）；北京市科技计划项目（D131100004713001） |
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| 中文摘要: |
| 继发性甲状旁腺功能亢进是慢性肾脏病的常见并发症，严重影响患者的生活质量和生存率。其发病机制主要包括低钙血
症、高磷血症、活性维生素D 缺乏、维生素D 受体及钙敏感受体表达下调等。近年来，成纤维细胞生长因子23在继发性甲状旁腺
功能亢进发病机制中的作用，也越来越受到重视。上述机制均可导致慢性肾脏病患者的甲状旁腺细胞增生，由多克隆增生逐渐发
展为单克隆增生、腺瘤等，甲状旁腺功能亢进也逐渐加重。现就慢性肾脏病继发性甲状旁腺功能亢进的发病机制的进展做一综
述。 |
| 英文摘要: |
| Secondary hyperparathyroidism(SHPT) is the common complication in chronic kidney disease which seriously affects
the patient's quality of life and decrease the survival rates. The pathogenesis of this disease includes: hypocalcemia, hyperphosphatemia,
the decreased levels of active vitamin D, vitamin D receptor and calcium-sensing receptor. Recently, the elevated level of fibroblast
growth factor 23 is also subjected to the value more and more. The above factors can induce parathyroid hyperplasia from polyclone,
monoclone, even adenoma, and SHTP may becomemore and more serious. In this review, the progress of pathogenesis in secondary hyperparathyroidismin
chronic kidney disease will be introduced. |
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