| 周婕 青胜兰 徐锋 张娜 刘元军.利妥昔单抗注射液联合化疗治疗B 细胞非霍奇金淋巴瘤的疗效观察[J].,2015,15(31):6143-6145 |
| 利妥昔单抗注射液联合化疗治疗B 细胞非霍奇金淋巴瘤的疗效观察 |
| Efficacy Observation of Rituximab Injection Combined with Chemotherapyin the Treatment of B-cell Non-Hodgkin Lymphoma |
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| DOI： |
| 中文关键词: 利妥昔单抗注射液 化疗 B 细胞非霍奇金淋巴瘤 疗效 |
| 英文关键词: Rituximab injection Chemotherapy B-cell Non-Hodgkin Lymphoma Efficacy |
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| 中文摘要: |
| 目的：观察利妥昔单抗注射液联合化疗治疗B 细胞非霍奇金淋巴瘤（B-NHL）的疗效。方法：将2013 年1 月至2014 年12 月
我院收治的71 例B-NHL患者分为对照组（n=35 例）和观察组(n=36 例)。对照组给予常规化疗方案进行治疗，观察组在此基础上
加用利妥昔单抗进行治疗，3个周期后评价其疗效及安全性。结果：观察组总有效率为91.67%，明显高于对照组的68.57%，对比差
异有统计学意义（x2=5.979, P<0.05）；观察组不良反应总发生率为41.67%，略低于对照组的45.71%，但无统计学差异（x2=0.118，
P>0.05）。结论：利妥昔单抗注射液联合化疗治疗B-NHL中期疗效显著，且无严重不良反应，值得临床推广。 |
| 英文摘要: |
| Objective:To observe the efficacy of Rituximab injection combined with chemotherapy in the treatment of B-cell
Non-Hodgkin Lymphoma (B-NHL).Methods:71 cases of patients with B-NHL treated in our hospital from January 2013 to December
2014 were divided into control group (n=35) and observation group (n=36), the control group was treated with conventional chemotherapy,
while the observation group was treated with Rituximab injection combined with chemotherapy, evaluated the clinical efficacy and safety
of two groups after 3 cycles treatment.Results:Total effective rate of observation group was 91.67%, which was significantly higher than
68.57%in control group, the difference was statistically significance (x2=5.979, P<0.05); Total incidence of adverse reactions in observation
group was 41.67%, which was slightly lower than 45.71% in control group, but the difference was not statistically significant(x2=0.
118, P>0.05).Conclusion:Rituximab injection combined with chemotherapy has remarkable mid-term efficacy in the treatment of
B-NHL, and without serious adverse reaction, which is worthy of application. |
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