| 范芮 王卯 李惠荣 仝晓蓉 李建.血清hs-CRP及红细胞分布宽度与急性冠脉综合征患者危险分层及预后的相关性研究[J].,2015,15(31):6139-6142 |
| 血清hs-CRP及红细胞分布宽度与急性冠脉综合征患者危险分层及预后的相关性研究 |
| Correlation of Serumhs-CRP and Red Blood Cell Distribution Width withRisk Stratification and Prognosis of Patients with Acute Coronary Syndrome |
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| DOI： |
| 中文关键词: 急性冠脉综合征 超敏C 反应蛋白 红细胞分布宽度 危险分层 |
| 英文关键词: Acute coronary syndrome Hypersensitive C-reactive protein Red blood cell distribution width Risk stratification |
| 基金项目:新疆昌吉回族自治州2013年科学研究与技术开发计划项目（2013S02-03） |
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| 中文摘要: |
| 目的：探讨血清超敏C 反应蛋白(hs-CRP)及红细胞分布宽度(RDW)与急性冠脉综合征(ACS)患者危险分层及预后的相关性。
方法：将132 例ACS 患者按照全球急性冠状动脉事件注册(GRACE) 危险评分分为低、中、高危三组；检测各组的血清hs-CRP、
RDW、肌钙蛋白I(cTnI)、B型脑钠肽(BNP)水平；并记录入院后心脏超声检查中左室射血分数(LEVF)及住院期间有无发生主要不
良心脏时间(MACE)等情况。结果：低、中、高危三组间血清hs-CRP、RDW、BNP、cTnI、LEVF 比较具有统计学差异(P＜0.05)，高危
组患者血清hs-CRP、RDW、BNP、cTnI 高于低危组及中危组(P＜0.05)，中危组高于低危组(P＜0.05)；血清hs-CRP 水平与GRACE
评分呈正相关(rs =0.490, P＜0.05)，RDW水平与GRACE 评分亦呈正相关(rs =0.401, P＜0.05)；与非MECE组比较，MECE组患者
hs-CRP、RDW较高(P＜0.05)；血清高水平hs-CRP 及RDW是ACS患者发生近期住院MACE 相关高危因素。结论：血清hs-CRP
及RDW水平随着ACS 患者危险分层的增加而增加，高水平hs-CRP 及RDW 是近期发生MACE 的高危因素，对临床评估ACS
患者病情及预后具有重要价值。 |
| 英文摘要: |
| Objective:To investigate the association of serum hypersensitive c-reactive protein (hs-CRP) and red blood cell distribution
width (RDW) with risk stratification and prognosis of patients with acute coronary syndrome (ACS).Methods:132 patients with
ACS were divided into low, medium and high risk groups according to the global registered acute coronary events (GRACE) risk score.
Serumhs-CRP, RDW, troponinI (cTnI), B-type brain natriuretic peptide (BNP) were detected; left ventricular ejection fraction (LEVF)
and major adverse cardiac time (MACE) in hospitalization were recoded.Results:There were statistical differences in hs-CRP, RDW,
BNP, cTnI, LEVF between low, moderate and high risk groups (P<0.05). The levels of hs-CRP, RDW, BNP, cTnI in high-risk group
were higher than in moderate-risk group and low-risk group (P<0.05), and those in moderate risk group were higher than in low-risk
group (P<0.05). Spearsman rank correlation analysis showed that the serum hs-CRP level was positively correlated with GRACE score
(rs=0.490, P<0.05), and RDW level was also positively correlated with GRACE score (rs=0.401, P<0.05). The levels of hs-CRP and
RDWof MECE group were higher than those of non-MECE group (P<0.05). Multivariable logistic regression analysis showed that high
levels of serum hs-CRP and RDWin patients with ACS were MACE-related risk factors for recent hospitalization.Conclusion:Serum
hs-RDWand hs-CRP levels increased with the increasing of risk stratification in ACS patients, high levels of hs-CRP and RDWare high
risk factors of recent MACE, and has an important value in clinical evaluation on condition and prognosis in patients with ACS. |
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