| 陈钧 杜莉 王佩 魏虹 韩祖成.环境光导致昼夜节律紊乱对睡眠的影响[J].,2015,15(31):6046-6049 |
| 环境光导致昼夜节律紊乱对睡眠的影响 |
| The Effects of Circadian Disruption by Environmental Light on Sleep |
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| DOI： |
| 中文关键词: 昼夜节律 睡眠觉醒 非快速动眼睡眠 快速动眼睡眠 |
| 英文关键词: Circadian Sleep-wake Non-rapid eye movement sleep (NREM) Rapid eye movement sleep (REM) |
| 基金项目:国家自然科学基金项目(81402055) |
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| 中文摘要: |
| 目的：研究通过环境光扰乱正常昼夜节律对睡眠的影响。方法：使用小鼠昼夜节律模型（20小时一个循环，10小时见光，10
小时避光），利用小鼠睡眠生物解析系统，记录脑电波和肌电波，分析睡眠觉醒量、不同时间睡眠觉醒波delta 功率和睡眠时相转换
等参数。结果：昼夜节律干扰后导致昼夜觉醒差异、非快速眼动睡眠差异（NREM），和快速眼动睡眠（REM）差异消失（P>0.05），昼
夜节律干扰后增加了觉醒和NREM睡眠之间的转换次数（P<0.05），昼夜节律紊乱的光照时相在开始时没有delta 功率减弱征象
（P>0.05）。结论：昼夜节律模型不会导致典型的睡眠剥夺，但是会对睡眠时间和质量会产生影响。本研究一步证实昼夜节律对睡眠
调节有着重要的作用。 |
| 英文摘要: |
| Objective:To study the effects of circadian disruption by environmental light on sleep.Methods:Disrupting the circadian
clock by altered light-dark cycles (a shortened 20 h day, 10 h light, 10 h dark;LD10:10), we used mouse sleeping analysis system to
record electroencephalogram and electromyogram, to analyze sleeping and awaking time in a day, delta power of sleeping and awaking
waves in different time，and times of sleeping and awaking switchover.Results:Environmental circadian disruption by light caused loss
of normal day-night differences in wake, non-rapid eye movement sleep (NREM), and rapid eye movement sleep (REM)(P > 0.05) between
light and dark phases. Circadian disruption increased the number of transitions between wake and NREM(P<0.05). Environmental
circadian disruption by light abolished the normally observed decrease in delta power at the onset of the light phase(P>0.05).Conclusion:Our results demonstrate that this model of circadian disruption did not lead to marked sleep deprivation, but instead affected the timing
and quality of sleep. |
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