| 卓惠长 赖国祥 柳德灵 宋颖芳 叶嘉.骨髓间充质干细胞在氨气致大鼠吸入性肺损伤的疗效观察[J].,2015,15(31):6017-6020 |
| 骨髓间充质干细胞在氨气致大鼠吸入性肺损伤的疗效观察 |
| Efficacy Observation of Bone Marrow Mesenchymal Stem Cells in AmmoniaInhalation Induced Lung Injury |
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| DOI： |
| 中文关键词: 骨髓间充质干细胞 氨气致大鼠吸入型肺损伤 疗效 |
| 英文关键词: Bone marrow mesenchymal stemcells Ammonia inhalation induced lung injury Efficacy |
| 基金项目:福建省自然科学基金计划项目（2013J01345） |
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| 中文摘要: |
| 目的：观察骨髓间充质干细胞在氨气致大鼠吸入性肺损伤的疗效。方法：随机选取69 只普通SD大鼠，随机将这些大鼠分为
正常组（n=23）、地塞米松治疗组（n=23）、干细胞治疗组三组（n=23），正常组给予尾静脉注射生理盐水，地塞米松治疗组给予注射
地塞米松，干细胞治疗组给予干细胞注射。结果：干细胞治疗组大鼠治疗后1 d、3 d的肺组织病理学评分及肺W/D、BALF白细胞
数量及蛋白浓度、TNF-alpha、IL-8 水平均显著低于地塞米松治疗组（P<0.05），均显著高于正常组（P<0.05）。结论：骨髓间充质干细胞
在氨气致大鼠吸入性肺损伤的疗效较地塞米松显著。 |
| 英文摘要: |
| Objective:To observe the efficacy of bone marrowmesenchymal stemcells in ammonia inhalation induced lung injury.Methods:69 cases of normal SD rats were randomly selected, the rats were randomly divided into normal group (n=23), dexamethasone
treatment group (n=23), stemcells treatment group (n=23) three groups, the normal group were given tail vein injection of saline, dexamethasone
treatment group were given injections of dexamethasone, stemcell therapy group were given injections of stemcells.Results:The lung histopathology scores and lungW/ D, BALF white blood cell count and protein concentration, TNF-琢, IL-8 1d, 3d after treatment
of the stemcell treatment group were significantly lower than the dexamethasone treatment group (P<0.05), were significantly higher
than the normal group (P<0.05).Conclusion:The efficacy of bone marrow mesenchymal stem cells in ammonia inhalation induced
lung injury is significant than Dexamethasone. |
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