| 涂玉亮 刘荣.肝萎缩增生复合征及肝萎缩病理和代谢功能研究进展[J].,2015,15(29):5797-5800 |
| 肝萎缩增生复合征及肝萎缩病理和代谢功能研究进展 |
| Progress on the Pathogenesis, Pathology and Physiological Functions of LiverAtrophy-hypertrophy Complex |
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| DOI： |
| 中文关键词: 肝萎缩增生复合征 病因 病理 代谢功能 |
| 英文关键词: Atrophy-hypertrophy complex(AHC) Pathogenesis Pathology Physiology |
| 基金项目:国家自然科学基金青年科学基金项目（81301239） |
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| 中文摘要: |
| 肝萎缩增生复合征(atrophy-hypertrophy complex, AHC)是指肝组织萎缩和代偿性增生的一种临床病理特征，常见的病因有
门静脉流入受阻、肝静脉流出受阻、胆道梗阻等。AHC常伴有区域性肝组织的解剖、病理、代谢功能的改变，包括肝脏沿肝门轴的
旋转、萎缩肝叶的纤维化和门管区小门静脉的狭窄或血栓形成等。肝萎缩- 增生复合征萎缩肝组织仍具有部分代谢功能和生物转
化功能，并可能对维持病变肝脏的正常肝功能具有重要的作用，萎缩肝组织仍具有部分代谢功能和生物转化功能，对萎缩肝组织
的代谢分区和代谢功能的进一步研究具有重要意义。本文通过分析近年来国内外有关AHC 的文献，探讨AHC的病因、病理变化
及萎缩肝组织的代谢功能分化特征的研究进展。 |
| 英文摘要: |
| To review the recent years literatures of the pathogenesis, pathology and physiological functions of liver atrophy-hypertrophy
complex (AHC) and to discuss the progress of them. Literatures ofNCBI PubMed and CBMdisc on research of the pathogenesis,
pathology and physiological functions of AHC were reviewed. Liver AHC refers to a clinical pathological characteristics on the compensatory
hypertrophy of liver parenchyma following hepatocyte loss. AHC is caused by portal vein obstruction, biliary obstruction and hepatic
vein obstruction, with the lesions of regional anatomy, pathology and metabolic function, including hepatic rotation along the hilar
axis, advanced septal fibrosis and stenosis or thrombosis of portal vein. There are some of functions of metabolism and biotransformation,
however they are rare to be studied. Preservation of the atrophy hepatic tissue plays an important role in maintaining normal liver function
in some lesions, and it is significant to further research the change of the metabolic zonation and metabolic function of atrophic liver. |
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