| 杨雅文 田成林 李倩 吕斌 于生元.脑梗死患者的脑白质病变危险因素分析[J].,2015,15(28):5475-5479 |
| 脑梗死患者的脑白质病变危险因素分析 |
| The Risk Factors of White Matter Lesion in Patients with Ischemic Stroke |
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| DOI： |
| 中文关键词: 脑白质病变 核磁共振成像 危险因素 |
| 英文关键词: White matter lesion Magnetic resonance imaging Risk factors |
| 基金项目:首都医学发展科研基金项目（2009-2037）；北京市自然科学基金项目（7123227） |
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| 中文摘要: |
| 目的：探索脑梗死患者中脑白质病变的危险因素。方法：以2012 年1 月至2014 年12 月我院神经内科收治的837 例脑梗死
患者为研究对象，采用Fazekas量表评价核磁共振T2WI脑室旁白质和皮质下白质病变严重程度。分别比较不同程度脑室旁白质
病变、皮质下白质病变患者间各个危险因素的差异，采用Logistic 回归分析脑白质病变的危险因素。结果：年龄、高血压是脑室旁
白质（OR 年龄=1.090，95%CI:0.073-0.099，P＜0.05；OR 高血压=1.699，95%CI:0.242-0.818，P＜0.05）和皮质下白质病变（OR 年龄
=1.074，95%CI:0.059-0.083，P＜0.05；OR高血压=1.353，95%CI:0.017-0.588，P＜0.05）共同的危险因素。收缩压（OR=1.008，95%CI:
0.001-0.015，P＜0.05）是皮质下白质病变的危险因素。结论：在脑梗死患者中，年龄、高血压是脑室旁白质病变、皮质下白质病变共
同的危险因素，收缩压是皮质下白质病变的危险因素。 |
| 英文摘要: |
| Objective:To explore the risk factors of white matter lesion (WML) in patients with ischemic stroke.Methods:837
consecutive patients with acute ischemic stroke who underwent MRI were enrolled in Neurology Department in PLA General Hospital
fromJanuary 2012 to December 2014. The severity of periventricular white matter lesion(PWML) and deep white matter lesion(DWML)
were evaluated using Fazekas scale. The risk factors were compared among different grades of PWML and DWML respectively. Logistic
regression was employed to find risk factors of PWML and DWML.Results：Age and hypertension were associated with the severity of
PWML (ORage=1.090, 95%CI: 0.073-0.099, P<0.05; ORhypertension=1.699, 95%CI: 0.242-0.818, P<0.05) and DWML (ORage=1.074,
95%CI: 0.059-0.083, P<0.05; ORhypertension=1.353, 95%CI: 0.017-0.588, P<0.05). SBP was associated with the severity of DWML
(OR=1.008, 95%CI: 0.001-0.015, P<0.05).Conclusion:Age and hypertension are risk factors of both PWML and DWML, and SBP is
the risk factor of DWML. |
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