| 李敏 王祖蕊 王莉 高沂 郭丽华.桔梗皂苷对烟雾致矽肺患者血清IL-8 和TNF-alpha水平的影响[J].,2015,15(26):5080-5082 |
| 桔梗皂苷对烟雾致矽肺患者血清IL-8 和TNF-alpha水平的影响 |
| Effect of Platycodin on the SerumIL-8 and TNF-alpha Levels of Patients withSmoke Induced Silicosis |
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| DOI： |
| 中文关键词: 桔梗皂苷 矽肺 白介素-8 肿瘤坏死因子-alpha |
| 英文关键词: Platycodon grandiflorum Silicosis IL-8 TNF-alpha |
| 基金项目:国家自然科学基金项目(30800902) |
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| 中文摘要: |
| 目的：探究桔梗皂苷对烟雾致矽肺患者血清白介素-8(IL-8)和肿瘤坏死因子-alpha(TNF-alpha)水平的影响。方法：选取我院呼吸科
2012 年6 月到2013 年6 月收治的68 例男性矽肺患者，并将其随机分为2 组。对照组34 例，给于矽肺宁片4 片/ 次，3 次/d，口
服；氨茶碱片0.1 g/ 次，3 次/d，口服；必漱平片16 mg/ 次，3 次/d，口服；舒喘灵片4.8 mg/ 次，3 次/d，口服；疗程24 周。实验组34
例，在常规治疗的基础上应用加用桔梗皂苷胶囊10 g/ 次，3 次/d，口服；疗程24 周。治疗结束后，检测和比较治疗前后两组患者
SaO2、PaO2、PaCO2、血清IL-8 和TNF-alpha的变化情况。结果：治疗后，两组患者的SaO2、PaO2、PaCO2水平均得到改善，实验组以上指
标较改善更为显著，差异具有统计学意义(P<0.05)。治疗后，两组患者的IL-8 和TNF-alpha水平均较治疗前显著下降，且实验组IL-8
和TNF-alpha水平显著低于对照组，差异具有统计学意义(P<0.05)。结论：桔梗皂苷辅助治疗能够显著改善烟雾致矽肺患者的呼吸功
能，降低血清IL-8 和TNF-alpha含量。 |
| 英文摘要: |
| Objective:To study the effect of platycodin on the serum IL-8 and TNF- alpha levels of patients with smoke induced
silicosis.Methods:68 male patients with smoke induced silicosis admitted in the Department of respiration in our hospital from June
2012 to June 2013 were selected and randomly divided into 2 groups. 34 patients in the control group were given Xi Feining tablet 4
tablets each time, 3 times/d, oral; Aminophylline Tablet 0.1 g/time, 3 times/d, oral; bromhexine hydrochloride tablet 16mg/time, 3
times/d, oral; salbutamol tablet 4.8 mg/time, 3 times/d, oral, the treatment cycle was 24 weeks. While 34 cases in the experimental group
were treated by platycodin capsules 10g/times on the basis of conventional therapy, 3/d, the treatment cycle was 24 weeks. After treatment,
the SaO2, PaO2, PaCO2 and serum levels of IL-8 and TNF- alpha of two groups were detected and compared before and after treatment.Results:After treatment, the SaO2, PaO2, PaCO2 levels in serum were significantly improved in both groups than those before treatment
(P<0.05), and the index mentioned above were improved more significantly in the experimental group than the control group(P<0.
05). After treatment, the IL-8 and TNF- levels in serum of both groups were significantly decreased, which were both lower in the experimental
group than those in the control group (P<0.05).Conclusion:Platycodin could significantly improve the respiratory function of patients
with smoke induced silicosis, decrease the serumIL-8 and TNF- alpha levels. |
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