| 邹红梅 黄志坚 李坚 叶青青 林斯 吴玫瑰 赖莉明 黄翠玲 董海鹏.吗丁啉和小剂量红霉素治疗极低出生体重儿喂养不耐受的疗效比较[J].,2015,15(25):4953-4955 |
| 吗丁啉和小剂量红霉素治疗极低出生体重儿喂养不耐受的疗效比较 |
| Comparison of the Efficacy of Domperidone and Low-dose Erythromycin inthe Treatment of Feeding Intolerance in very Low Birth Weight Infant |
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| DOI： |
| 中文关键词: 吗丁啉 红霉素 极低出生体重儿 喂养不耐受 |
| 英文关键词: Domperidone Erythromycin Very low birth weight infant Feeding intolerance |
| 基金项目:广东省人口计生委项目（20133097） |
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| 中文摘要: |
| 目的：比较吗丁啉和小剂量红霉素治疗极低出生体重儿喂养不耐受的临床疗效。方法：回顾性分析我科2011 年1 月至2013
年12 月期间收治的90 例极低出生体重儿喂养不耐受患儿的临床资料。根据选用的治疗药物，将患儿分为A 组(吗丁啉组，n=42)
和B 组(小剂量红霉素组，n=48)两组。患儿在综合治疗的基础上配合上述的药物治疗喂养不耐受的症状。观察并比较两组患儿喂
养不耐受症状的消退时间、恢复出生体重时间、完全胃肠内喂养时间、住院时间及治疗副作用的发生情况。结果：两组患儿经积极
干预治疗后，喂养不耐受症状消失、恢复出生体重、完全胃肠内营养等出院标准。两组患儿间上述指标实现时间及住院时间的比
较未见统计学差异(P>0.05)；A组患儿治疗期间未见与服用吗丁啉相关的不良反应；B组患儿有6例因静滴红霉素引起的局部疼
痛发生，发生率为12.5%，未见静脉炎等不良反应发生。两组患儿间治疗副作用发生率的比较，差异具有统计学意义( P<0.05)。结
论：吗丁啉和静滴低剂量红霉素均可有效治疗极低出生体重儿的喂养不耐受症状。二者的治疗效果相当，但吗丁啉可能具有更高
的安全性。 |
| 英文摘要: |
| Objective:To compare the efficacy of domperidone and low-dose Erythromycin in the treatment of feeding intolerance
in very low birth weight infant （VLBWI）Methods:A retrospective analysis was performed on 90 cases of VLBWI with feeding
intolerance who admitted in our hospital from January 2011 to December 2013. According to the choice of therapy, the patients were
divided into groupA (domperidone group, n=42) and groupB (low-dose erythromycin group, n=48). On the basis of comprehensive
treatment the children of different groups were treated with different drugs as mentioned above the feeding intolerance symptoms.then the
subside time of feeding intolerance symptoms, time to regain birth weight, the incidence of total parenteral feeding time, duration of
hospitalization and incidence of side effects were observe and compared between two groups.Results:After treatment，all the children in
both groups，achieved feeding intolerance symptoms, regained birth weight, total parenteral nutrition in the discharge standards. No
statistically significant difference was found in the time of indicators mentioned above between two groups (P>0.05). No related adverse
reactions was adversed in group A，while six cases of local pain caused by intravenous erythromycin was adversed in group B，the
incidence rate was 12.5%,it was significantly higher than that of groupA (P <0.05).Conclusion:Both domperidone and low-dose
intravenous erythromycin could be effective and equal in the treatment of feeding intolerance in VLBWI. But domperidone might have
higher security. |
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