| 曹雪峰 刘春荣 周秀艳 张燕 白华.糖尿病肾病患者血浆基质金属蛋白酶-2 和同型半胱氨酸水平及其临床意义[J].,2015,15(25):4916-4918 |
| 糖尿病肾病患者血浆基质金属蛋白酶-2 和同型半胱氨酸水平及其临床意义 |
| Analysis of Test Results of Diabetic Nephropathy Patients Plasma MatrixMetalloproteinase -2 and Homocysteine |
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| DOI： |
| 中文关键词: 糖尿病肾病 同型半胱氨酸 基质金属蛋白酶-2 |
| 英文关键词: Diabetes nephropathy Homocysteine MMP-2 |
| 基金项目:唐山市科技局科研项目（13130274b）；国家自然科学基金项目(30672763) |
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| 中文摘要: |
| 目的：探讨糖尿病肾病患者血浆基质金属蛋白酶-2 和同型半胱氨酸水平及其临床意义。方法：选取糖尿病患者71 例，其中
并发糖尿病肾病组(n=35)和未并发肾病组(n=36)，同时选取健康人群40 例为对照组。检测患者MMP-2、Hcy、MAU及Scr水平。结
果：糖尿病肾病组、糖尿病无肾病组血浆MMP-2、Hcy及MAU水平均显著高于健康对照组(P＜0.01)；与糖尿病无肾病组比较，糖
尿病肾病组患者MMP-2、Hcy及MAU水平较高(P＜0.05)；糖尿病肾病组患者的血浆SCr 水平明显高于其他两组(P＜0.05)。糖尿
病肾病患者血浆MMP-2 与MAU 呈显著正相关(r=0.522，P＜0.05)，与Hcy 呈显著负相关(r=-0.007，P＜0.05)，与Scr 不相关(P>0.
05)；Hcy与MAU(r=0.012，P＜0.05)、Scr均(r=0.031，P＜0.05)呈正相关。结论：糖尿病肾病患者MMP-2 水平降低，Hcy 水平升高，
有望作为糖尿病肾病患者的诊断和预后预测参考指标。 |
| 英文摘要: |
| Objective:To investigate the changes of plasma matrix metalloproteinase -2 (MMP-2) and homocysteine (Hcy) in
diabetic nephropathy diagnosis value.Methods:71 cases of patients with diabetes were selected, which complicated with diabetic
nephropathygroup (n=35) and non diabetic nephropathy group (n=36), and selecting the healthy people in our hospital outpatient
department of internal medicine examination in 40 cases as control group. MMP-2 and Hcy levels in patients were detected, the
simultaneous detection of MAU, Scr, and the testing results are statistical analysis.Results:Hcy, plasma MMP-2 and MAU levels of
diabetic nephropathy group, diabetes nephropathy group were significantly higher than those in healthy control group (P<0.01), MMP-2
and MAU levels of diabetic nephropathy group were higher than without nephropathy group (P<0.01). The plasma SCr level in patients
with diabetic nephropathy group were significantly higher than the other two groups (P < 0.05); According to the correlation analysis,
Diabetic nephropathy patients with positive plasma MMP-2 MAU and SCr, and negatively correlated with Hcy.Conclusion:MMP-2 and
Hcy decreased gradually with the MMP-2 level of diabetic nephropathy, Hcy levels increased gradually. Diabetic nephropathy patients
MMP-2, MAU, plasma Hcy and Scr were correlated, suggesting that renal function in patients with diabetes increased with aggravation of
diabetes, has guiding significance for clinical. |
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