| 路英杰 王立峰 张建冰 王晓云.电阻抗法在急性冠脉综合征患者中的应用[J].,2015,15(23):4555-4557 |
| 电阻抗法在急性冠脉综合征患者中的应用 |
| Application of the Impedance Platelet Aggregometry in Patientswith Acute Coronary Syndrome |
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| DOI： |
| 中文关键词: 电阻抗法 氯吡格雷抵抗 急性冠脉综合征 |
| 英文关键词: Impedance platelet aggregometry Clopidogrel resistance Acute coronary syndrome |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨电阻抗法测定血小板聚集功能在冠心病患者中的应用。方法：通过电阻抗法对486 名急性冠脉综合征的患者检
测，所有患者分别于服药前和服药后第4 天抽取肘静脉血，采血后1 小时内用全血阻抗法测定三磷酸腺苷(ADP)和花生四烯酸
(AA)诱导的血小板聚集率；其中50 例患者出现氯吡格雷抵抗，28 例患者出现阿司匹林抵抗。结果：通过电阻抗法测定的抗血小板
药物抵抗的发生率(10.29 %)与文献报道的一致；在原来抗血小板药物基础增加西洛他唑或者增加氯吡格雷的剂量都能明显改善
血小板药物抵抗，随着服药时间的增加血小板药物抵抗呈下降趋势；大剂量氯吡格雷组相比西洛他唑组在改善氯吡格雷抵抗更
明显，差异有统计学意义（P<0.05）。结论：电阻抗法测定血小板聚集功能方便快捷、安全可靠，更方便指导临床用药。 |
| 英文摘要: |
| Objective:To explore the application value of impedance platelet aggregometry in the determination of the platelet
aggregation function in patients with coronary heart disease (CHD).Methods:486 patients with acute coronary syndrome were enrolled
and the platelet aggregation function was detected by impedance platelet aggregometry determination. All the patients were extracted
thrhough elbow venous before taking medication and 4 days later，using whole blood impedance method to detect platelet aggregation
rate through adenosine triphosphate (ADP) and arachidonic acid (AA)within 1 hour. Among these, there were 50 patients who had
Clopidogrel resistance, and 28 patients who had Aspirin resistance.Results:With the increase of dose, Cilostazol or Clopidogrel can
obviously improve the resistance of the antiplatelet drug on the basis of the original antiplatelet drugs; with the prolongation of taking
medicine, the resistance of antiplatelet drug was on the decline; compared with the Cilostazol group, the clopidogrel group of high dose
was more obvious in improving clopidogrel resistance, and the difference was statistically significant (P<0.05）Conclusion:Impedance
Platelet Aggregometry is quick, safe and reliable to detect platelet aggregation rate, and it is convenient to guide the clinical medication. |
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