| 姜秀秀 叶明翔 张信信 李 楠蓸晶 常宁 张艰.泛素连接酶SCFFBW7调控的靶蛋白研究进展[J].,2015,15(22):4394-4396 |
| 泛素连接酶SCFFBW7调控的靶蛋白研究进展 |
| Progress onUbiquitin-proteinEnzyme SCFFBW7RegulatingTarget Proteins |
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| DOI： |
| 中文关键词: 肿瘤 癌蛋白 FBW7 泛素-蛋白酶体途径 |
| 英文关键词: Tumor Oncoprotein FBW7 Ubiquitin-proteasome pathway |
| 基金项目:国家自然科学基金项目（81272518） |
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| 中文摘要: |
| FBW7(F-box and WD repeat domain-containing7，FBW7)为F-box 蛋白家族成员，是SCF 型泛素连接酶复合物的底物识别蛋
白，介导细胞内多种蛋白质经泛素- 蛋白酶体途径降解。FBW7 通过靶向降解多种癌蛋白如Mcl-1、Notch、HIF-1alpha、Cyclin E和
KFL5 等，参与调控细胞增殖、分化、凋亡及肿瘤转移等多种生物学过程。作为一种肿瘤抑制蛋白，FBW7 基因突变或缺失存在于多
种人类肿瘤中，如白血病、乳腺癌、卵巢癌、胆管癌等，并在这些肿瘤的发生和发展中发挥重要作用。因此，针对FBW7 的深入研究
有助于理解肿瘤的发生发展机制以及开发肿瘤治疗新方案。本文就FBW7 调控的癌蛋白研究进展作一综述。 |
| 英文摘要: |
| FBW7(F-box and WD repeat domain-containing7, FBW7) is a member of F - box protein family, seving as a substrate
recognition unit of the SCF ubiquitin protein enzyme complex. FBW7 mediates the ubiquitylation of several oncoproteins, like Mcl-1,
Notch, HIF-1alpha, Cyclin E and KFL5, and promotes their degradation via the ubiquitin - proteasome pathway. Therefore , FBW7 plays a
key role in regulating a variety of biological processes such as cell cycle progression, cell proliferation, differentiation, apoptosis and
tumor metastasis. As a tumor suppressor, gene deletion or mutations of FBW7 have been identified in various types of human tumor
including leukemia, breast cancer, ovarian cancer and bile duct carcinoma. Therefore, research into FBW7 is of vital importance for a
better understanding of tumorigenesis and cancer progression, and for developing novel targets for cancer therapy. This review
summarizes the progression on the ubiquitin-protein enzyme SCFFBW7regulating oncoproteins. |
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