| 李力 邓迎丽 卜荣蓉 阳曼丽 吴贵全 周辉.经支气管镜治疗96 例难治性肺炎临床观察[J].,2015,15(21):4078-4080 |
| 经支气管镜治疗96 例难治性肺炎临床观察 |
| Bronchoscopic Treatment of 96 Cases of Refractory Pneumonia |
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| DOI： |
| 中文关键词: 难治性肺炎 支气管镜 肺通气功能 |
| 英文关键词: Refractory Pneumonia Bronchoscopy Pulmonary Ventilation Function |
| 基金项目:安康市科技技术局项目（20120914）；长沙市科技计划项目（k1307023-31）；湖南省财政厅科技项目（湘财社指（2014）30 号） |
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| 中文摘要: |
| 目的：探讨经支气管镜吸痰、灌洗和注药治疗难治性肺炎的临床疗效和安全性。方法：96 例确诊的难治性肺炎患者被随机分
为观察组和对照组，每组均为48 例。对照组采用针对性和经验性常规治疗；观察组在常规治疗基础上行经支气管镜局部吸痰、灌
洗和注药。比较两组治疗情况、通气功能和血气指标变化、疗效及不良反应情况等。结果：观察组住院时间和病灶好转时间仅为
(12.45± 3.25)d 和(19.32± 3.86)d 均显著低于对照组住院和病灶好转时间(P<0.05)，而住院费用仅为(30721.00± 1004.00)元，显著
少于对照组(P<0.05)；治疗后体温、CRP、WBC、RR 和HR 水平分别下降到(36.74± 0.40)℃、(34.9± 3.0) mg/L、(9.49± 1.20) × 109/L
、(21± 5) 次/min 和(84± 8) 次/min，显著低于治疗前和对照组治疗后水平(P<0.05)；总有效率为83.33%显著高于对照组52.08%
(P<0.05)，细菌培养阳性率85.42％，显著高于细菌培养阳性率29.17％(P<0.05)；术后无严重并发症。结论：在常规治疗基础上经纤
维支气管镜局部吸痰、灌洗和注药治疗难治性肺炎，能改善患者肺通气功能，提高临床治疗效果，缩短病程。 |
| 英文摘要: |
| Objective:To investigate the clinical efficacy and safety of bronchoscopy sputum suction, douche and injection for the
treatment of refractory pneumonia.Methods:96 cases of refractory pneumonia patients were randomly divided into observation group
and control group were 48 cases. Control group use targeted and empirical routine treatment; the observation group in the conventional
treatment based uplink bronchoscopic suctioning, lavage and local drug injection. Compared two groups of treatment, change, function
and blood indexes of ventilation efficacy and adverse reaction.Results:in the observation group, hospitalization time and lesion improvement
time was (12.45 ± 3.25) D and (19.32 ± 3.86) d was significantly lower than the control group in hospital and lesion improvement
time (P<0.05), and cost of hospitalization was (30721 ± 1004) yuan, significantly less than the control group (P<0.05); treatment temperature,
CRP, WBC, RR and HR levels were decreased to (36.74 ± 0.40) ℃ , (34.9 ± 3) mg/L, (9.49 ± 1.20) × 109/L, (21 ± 5) /min and
(84 ± 8) /min was significantly lower than that before treatment, and the control group after treatment (P<0.05); the total level efficiency
of 83.33%was significantly higher than that in control group 52.08% (P<0.05), bacterial culture positive rate was 85.42%, significantly
higher than that of bacteria culture positive rate was 29.17% (P<0.05); no serious postoperative complications.Conclusion:on the basis
of conventional therapy with bronchoscope sputum suction, lavage and injection for the treatment of refractory pneumonia, can improve
the pulmonary ventilation function of patients, improve the clinical treatment effect, shorten the course of disease. |
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