| 云俊杰 王健 徐影 张黎瑛 金雅琴 董佳琦.FeNO在慢性阻塞性肺疾病急性发作期患者中的临床应用[J].,2015,15(21):4074-4077 |
| FeNO在慢性阻塞性肺疾病急性发作期患者中的临床应用 |
| Fractional Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 呼出气一氧化氮浓度 一秒用力呼气容积 |
| 英文关键词: COPD FeNO FEV1 |
| 基金项目:上海市卫计委《青年医师培养资助计划》 |
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| 中文摘要: |
| 目的：探讨呼出气一氧化氮浓度(FeNO)在慢性阻塞性肺疾病急性期(AECOPD)患者中的变化情况及与一秒用力呼气容积
(FEV1)的关系。方法：选取上海第九人民医院2013 年8 月~2014 年2 月呼吸内科病区治疗的AECOPD 患者30 例，目前仍在吸
烟或患有哮喘、自身免疫性疾病及肿瘤的患者排除在外。对照组选取18 例健康的体检老年人。入组患者在治疗前先测定FeNO、
FEV1 值及完成CAT 评分，并进行病情分组。治疗后再次测定FeNO、FEV1 %值。结果：治疗前实验组FeNO、FEV1 %水平与对照
组相比有统计学差异(P<0.01)。治疗后实验组FeNO与对照组相比，无统计学差异(P>0.05)。而治疗前后两组间FEV1%变化有统计
学差异(P<0.01)。实验组不同亚组治疗前后FeNO、FEV1 %变化有统计学差异(P<0.05)，且治疗前FeNO与FEV1 %呈负相关(r=-0.
098，P=0.042)，治疗后FeNO与FEV1 %无明显相关(r=-0.248，P=0.784)。结论：FeNO可反映COPD急性期患者气道慢性炎症控制
情况，且对提示预后有一定意义。 |
| 英文摘要: |
| Objective:To evaluate the clinical significance of fractional exhaled nitric oxide (FeNO) in patients with acute exacerbation
of chronic obstructive pulmonary disease (AECOPD), and to evaluate the correlation between FeNO and FEV1%.Methods:30 patients
with AECOPD were selected as the experience group from August 2013 to February 2014 treated in the department of respiration
in Shanghai the ninth People's Hospital. These patients suffered from asthma and tumor and autoimmune diseases was excluded as the
same as smoking. 18 old healthy people were selected as the control group. The FeNO and FEV1%were examined before the treatment
as soon as the CAT scale was completed to discriminate severity of AECOPD. The FeNO and FEV1% were examined after treatment
again.Results:The FeNO and FEV1%was different between control group and experience group before the treatment (P<0.01). After the
treatment, the change of FeNO in experience group was not different compared with the control group (P>0.05), but the change of
FEV1%was different (P<0.01). The changes in experience group were different after the treatment (P<0.05). Before the treatment there is
a negative correlation between FeNO and FEV1% (r=-0.098，P=0.042). After the treatment there is not any correlation between FeNO
and FEV1%(r=-0.248，P=0.784).Conclusion:FeNO can be considered as a marker of airway inflammation, and can be used in forecasting
the prognosis in patients with AECOPD. |
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