| 彭慧 戚欣 李静.STAT3 与在肿瘤耐药中的研究进展[J].,2015,15(19):3789-3793 |
| STAT3 与在肿瘤耐药中的研究进展 |
| Signal Transduction and Activator of Transcription 3and its Development in Tumor Resistance |
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| DOI： |
| 中文关键词: STAT3 肿瘤耐药 耐药机制 治疗 |
| 英文关键词: STAT3 Tumor resistance Resistance mechanisms Therapy |
| 基金项目:国家自然科学基金项目（81373323） |
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| 中文摘要: |
| STAT3 是信号转导与转录活化蛋白（STATs）家族的重要一员，是一种存在于胞浆并在激活后能够转入核内与DNA结合的
蛋白家族，具有信号转导和转录调控双重功能。STAT3 在多种肿瘤组织与细胞系中异常表达，并与肿瘤的增殖分化、细胞凋亡密
切相关。肿瘤耐药是其治疗失败的重要原因，STAT3 能够通过多种途径介导肿瘤耐药。因而，STAT3在近年的抗肿瘤研究中备受
关注，成为肿瘤治疗的良好靶点，由传统药物与STAT3 抑制剂组成的新型治疗方案使得肿瘤患者大大受益。然而，STAT3 介导肿
瘤耐药的机制还不是很明确，需要进一步研究。本文就近年来一些化疗药物和靶向药物耐药的发生，对STAT3 介导耐药的作用
进行综述。 |
| 英文摘要: |
| STAT3 is an important member of signal transduction and activator of transcription (STATs) family. STATs protein
family are present in the cytoplasm, after being activated they can transfer to the nucleus and bind to DNA. It has a dual function in signal
transduction and transcriptional regulation. A variety of tumor tissues and cell lines have abnormal expression of STAT3, it is closely
related to the progression, differentiation and apoptosis of cancer. Tumor drug resistance is an important cause of treatment failure,
STAT3 can mediate tumor resistance through a variety of ways. Hence, recently STAT3 has attracted much attention in anticancer
research, become a good target for cancer therapy. STAT3 inhibitor combined with traditional medicine formed a new treatment program,
which benefit much for cancer patients. However, the mechanism of STAT3-mediated tumor resistance is not very clear and further
research is needed. In this paper, we describe some of the chemotherapy and targeted drugs resistance occurred in recent years, and
review the role of STAT3-mediated resistance. |
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