| 王亚锦 胡迎芬 王洋 姜颖 马爱国.铁过载对大鼠骨髓及肝脾组织的影响[J].,2015,15(19):3641-3644 |
| 铁过载对大鼠骨髓及肝脾组织的影响 |
| Effect of Iron Overload on Bone Marrow, Liver and Spleen in Rats |
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| DOI： |
| 中文关键词: 右旋糖酐铁 铁过载 血清铁 |
| 英文关键词: Iron dextran Iron overload Serumiron |
| 基金项目:国家自然科学基金项目（81373000） |
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| 中文摘要: |
| 目的：通过腹腔注射右旋糖酐铁建立铁过载大鼠模型，观察过量补铁对大鼠骨髓及肝脾组织的影响。方法：雄性Wistar大鼠
40 只随机分为：正常对照组、低剂量铁组、中剂量铁组和高剂量铁组。经隔日腹腔注射每次分别给予右旋糖酐铁0.9 mg、0.3 mg、9
mg、18 mg，共干预6 周。观察各组大鼠的生长发育状况并检测相关指标。结果：四组大鼠白细胞计数、红细胞计数、血红蛋白浓度
以及血小板计数差异均无统计学意义(P＞0.05)。骨髓外铁含量分析，中、高剂量铁组大鼠骨髓基质中均出现不同程度的铁蓄积，
骨髓细胞外铁含量均显著高于正常对照组（P＜0.05）。与正常对照组比较，中、高剂量铁组大鼠肝脏系数分别升高52%和148%
（P＜0.05），脾脏系数分别升高56%和100%（P＜0.05）。与正常对照组比较，中、高剂量铁组大鼠肝组织铁分别升高154 %和303%
（P＜0.05），脾组织铁分别升高40%和127%（P＜0.05），血清铁含量分别升高35%和165%（P＜0.05）。结论：过量补铁（腹腔给药）
可使大鼠骨髓基质出现铁沉积，肝脏和脾脏脏器系数及其组织铁含量显著增加，导致铁在机体内过量蓄积。因此临床铁补充应防
止过量长期用药。 |
| 英文摘要: |
| Objective:To explore the effects of the iron dextran on bone marrow, liver and spleen in iron overload rats.Methods:Forty Wistar male rats were randomly divided into four groups including control group (0.9 mg), low-dose iron group (0.3 mg),
middle-dose iron group (9 mg) and high-dose iron group (18 mg), then were injected with intraperitoneal iron dextran every other day for
six weeks. The general situation and the related indicators were detected.Results:There was no significant difference in white blood
cells, red b1ood cells, hemoglobin and platelets among these groups (P＞0.05). Compared with the control group, the iron content of
bone marrow in the middle-dose iron group and the high-dose iron group were significantly higher than that of the control group (P＜
0.05). Compared with the control group, the liver coefficient and the spleen coefficient of the middle-dose iron group and high-dose iron
group was increased by 52%, 148%, 56%and 100%respectively (all P＜0.05). Compared with control group, the iron concentration of
the liver and spleen in the middle-dose iron group and high-dose iron group was increased by 52%, 148%, 40%and 127% (all P＜0.05),
and the serumiron was increased by 35%and 165% (P＜0.05).Conclusion:Even the iron overload doesn’t impact on peripheral blood
of rats, but inhibits the function of rat bone marrow, liver and spleen significantly. |
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