| 李晶晶 陈逸伦 马永东 高洁 耿晓雯 任艺虹.替格瑞洛与氯吡格雷对急性冠脉综合征患者经皮冠脉动脉介入术后血小
板抑制效果的比较[J].,2015,15(18):3462-3465 |
| 替格瑞洛与氯吡格雷对急性冠脉综合征患者经皮冠脉动脉介入术后血小
板抑制效果的比较 |
| Comparison of Ticagrelor with Clopidogrel in the Treatment of Patients withAcute Coronary Syndrome in Platelet Reactivity |
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| DOI： |
| 中文关键词: 急性冠脉综合征 血小板抑制率 替格瑞洛 氯吡格雷 |
| 英文关键词: Acute coronary syndrome Platelet inhibition ratio Ticagrelor Clopidogrel |
| 基金项目:国家自然科学基金项目（81270309） |
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| 中文摘要: |
| 目的：比较替格瑞洛与氯吡格雷对急性冠脉综合征(ACS)患者经皮冠脉动脉介入术(PCI)后血小板的抑制效果。方法：选择
2014年3 月至8月在我院经替格瑞洛联合阿司匹林治疗的ACS 患者85 例(替格瑞洛组)，按性别、年龄2:1 匹配原则随机抽取同
一时间服用氯吡格雷联合阿司匹林治疗患者170 例(氯吡格雷组)为研究对象，两组患者均行PCI治疗，并于服用抗血小板药物负
荷剂量2 天(PCI术后)进行血栓弹力图(TEG)检测，观察和比较两组患者经ADP途径及经AA 途径的血小板抑制率。结果：氯吡格
雷组和替格瑞洛组经ADP 途径的血小板抑制率分别为(66.60± 25.57)%、(82.10± 18.87)%，两组比较差异有统计学意义(P<0.05)。
氯吡格雷组ADP 抑制率<50%患者占总人数的29.4%，替格瑞洛组ADP 抑制率<50%的患者占总人数的10.6%，两组差异有统计
学意义(P<0.05)，氯吡格雷组ADP抑制率>75%者占总人数的41.8%；而替格瑞洛组ADP抑制率>75%的患者占总人数的69.4%，
两组抑制率差异也存在统计学意义(P<0.05)。氯吡格雷组和替格瑞洛组经AA 途径的血小板抑制率分别为(88.70± 23.89)%、
(90.32± 18.09)%，两组比较差异无统计学意义(P>0.05)。结论：替格瑞洛对ACS患者PCI术后血小板的抑制作用优于氯吡格雷。 |
| 英文摘要: |
| Objective:To compare the inhibitory effect of ticagrelor and clopidogrel on the platelet of patients with acute coronary
syndrome(ACS) after percutaneous coronary artery intervention(PCI).Methods:255 cases of patients with ACS admitted in our hospital
from March 2014 to August 2014 were selected for this study, in which 85 cases were treated by ticagrelor and aspirin and the other 170
cases were treated by clopidogrel and aspirin respectively. All the patients were given PCI treatment, and the thrombelastography(TEG)
were detected 2 days after PCI and oral administration of load dosage of antiplatelet drugs, the latelet inhibition ratio through ADP and
AA pathway were observed and compared between the two groups.Results:Adenosine diphosphate (ADP)-induced platelet inhibition
ratio in clopidogrel group was (66.60± 25.57)%, which was (82.10± 18.87)%in the ticagrelor group and significantly higher than that of
the clopidogrel group (P<0.05). Arachidonic acid(AA)-induced platelet inhibition ratio were (88.70± 23.89)%, (90.32± 18.09)% in the
clopidogrel group and the ticagrelor group. There was no significant difference in the AA -induced platelet inhibition ratio between two
groups (P>0.05). The percentages of patients with ADP-induced platelet inhibition ratio<50% were 29.4%and 10.6% in the clopidogrel
group and ticagrelor group, there were significant differences between two groups (P<0.05). The percentages of patients with
ADP-induced platelet inhibition ratio>75% were 41.8% and 69.4% in the clopidogrel group and the ticagrelor group, respectively, and
there were significant differences between the two groups (P<0.05).Conclusion:Ticagrelor had greater inhibitory effect on the patients
with ACS after PCI than Clopidogrel. |
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