| 谢艳华 郭军 杨倩 王四旺 李予蓉.红芪胶囊对低剂量辐射损伤小鼠的保护作用[J].,2015,15(18):3452-3457 |
| 红芪胶囊对低剂量辐射损伤小鼠的保护作用 |
| The Protective Effect of Hongqi Capsule on Low-dose Radiation InjuredMice |
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| DOI： |
| 中文关键词: 红芪胶囊 低剂量辐射 放射性损伤 保护作用 |
| 英文关键词: Hongqi capsule Low-dose radiation Radiation injury Protective effect |
| 基金项目:陕西省"13115" 科技创新工程重大科技专项项目（2009ZDKG-75）；陕西省中医管理局中医药科研课题（2011-jc50）；
秦巴山区中药发展协同创新中心培育项目（NO201200CP-01-01） |
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| 中文摘要: |
| 目的：采用低剂量辐射损伤小鼠模型，观察红芪胶囊的药理作用。方法：二级昆明种小鼠216 只，除正常组36 只外，其余180
只采用多次低剂量累积辐射。将照射的180 只小鼠按体重随机分为5组，每组12 只，分别为：模型组，阳性对照组（1.20 g/kg），红
芪胶囊小剂量组（0.175 g/kg），红芪胶囊中剂量组(0.35 g/kg)，红芪胶囊大剂量组(0.70 g/kg)；将未照射的36 只小鼠设为正常组，每
组又分为给药6、12、24 d三个时间点，每时间点12 只动物。各组在末次照射当天分别灌胃上述药物，正常对照组及模型对照组灌
胃等量蒸馏水，每日一次，连续给药24 d，观察红芪胶囊的药理作用。结果：①红芪胶囊给药12 d、24 d对辐射损伤小鼠的外周血
象红细胞（RBC）、白细胞（WBC）、血小板（PLT）和血红蛋白含量（HGB）有明显的升高作用（P<0.01 或P<0.05）；②明显增加辐射损
伤小鼠的肝脏、脾脏、大脑和睾丸组织的湿质量（P<0.01 或P<0.05）；③镜下观察可见红芪胶囊能明显改善损伤小鼠骨髓细胞活
性。结论：红芪胶囊对低剂量辐射损伤具有一定保护作用。 |
| 英文摘要: |
| Objective:To investigate the pharmacological effects of Hongqi capsule on low-dose radiation injured mice.Methods:216 Kunming mice were divided into normal group and experiment group. There were 36 mice in the normal group, while 180 in the
experiment group were irradiated by multiple low-dose radiation, and then they were randomly divided into five groups of 12 each:the
model group, the positive control group (1.20g/kg), Hongqi capsule small dose group (0.175g/kg), Hongqi capsule middle dose group
(0.35g/kg), and Hongqi capsule high-dose group (0.70g/kg); 36 non-irradiated mice were divided into the normal group, each group was
administrated for 6, 12, 24 days, respectively. Every group was administered the drugs on the day of the last irradiation, and the normal
control group and model control group were given distilled water, once-daily. The pharmacological effects of Hongqi capsule after
continuous administration of 24 days were detected.Results:① Hongqi capsule increased the red blood cell (RBC), white blood cell
(WBC), platelet (PLT) and hemoglobin content (HGB) of radiation injured mice in peripheral blood after administration for 12 and 24
days. (P<0.01 or P<0.05); ② Hongqi capsule increased the wet weight of liver, spleen, brain and testicular tissue (P<0.01 or P<0.05); ③
Hongqi capsule increased improved marrow cell activity in microscope.Conclusion:Hongqi capsule certainly has protective effect on
low-dose injured mice. |
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