| 杜君丽 高成芳 单丽娜 范燕宾 杨巍.microRNA在常见致死性心脏病中的改变[J].,2015,15(17):3386-3388 |
| microRNA在常见致死性心脏病中的改变 |
| microRNA Changes Common Fatal Heart Disease |
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| DOI： |
| 中文关键词: miRNA 冠状动脉疾病 心肌梗死 心力衰竭 |
| 英文关键词: miRNA Coronary artery disease Acute myocardial infarction Heart failure |
| 基金项目:国家自然科学基金项目(81271676） |
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| 中文摘要: |
| 微小RNA( microRNA,miRNA)是一类真核生物内源性非编码单链的小RNA分子，长度大约为19-23 个核苷酸，拥有高度
的保守性，不编码蛋白质，也是近年来研究最热门的一个新领域，通过与靶mRNA特异性结合来调节基因表达，且表达都具有组
织特异性。最近，许多研究表明miRNA在心血管系统疾病和肿瘤疾病方面的相关研究都取得了突破性的进展，miRNA在肿瘤疾
病中是通过调节癌基因及抑癌基因而调控肿瘤的生物学过程，在心血管系统疾病中与心肌肥厚及心肌再生等过程有密切的关
系，包括冠状动脉疾病、心肌肥大、心肌梗死、心律失常、高血压和心力衰竭等疾病，且在心脏病学中扮演着及其重要的角色。
MiRNA的表达量增加或者减少对心血管疾病都有影响，该文对新近有关的miRNA在心血管系统疾病中的研究进展、诊断、治疗
以及预后予以综述。 |
| 英文摘要: |
| Micro RNA (microRNA, miRNA) are a class of small RNA molecules derived eukaryotic non-coding single stranded,
about 19-23 nucleotides in length, with a highly conserved, not encode proteins, recent studies also one of the hottest new areas, through
specific binding to target mRNA to regulate gene expression, and the expression is tissue specific. Recently, many studies have shown
that miRNA-related research in cardiovascular disease and cancer diseases have made a breakthrough, miRNA in cancer diseases by
regulating oncogenes and tumor suppressor genes and regulation of biological processes in the cardiovascular system diseases are closely
related to cardiac hypertrophy and cardiac regeneration process, including coronary artery disease, myocardial hypertrophy, myocardial
infarction, arrhythmia, hypertension and heart failure and other diseases, and plays its important role in cardiology. MiRNA expression of
the increase or decrease of cardiovascular disease has an impact on the research progress in recent miRNA-related diseases of the
cardiovascular system, diagnosis, treatment and prognosis to be reviewed. |
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