| 谢聪钦 马远征 李大伟 刘泽民 黄新 刘志 刘飞.IL-33 在强直性脊柱炎患者外周血中的表达及意义[J].,2015,15(17):3247-3249 |
| IL-33 在强直性脊柱炎患者外周血中的表达及意义 |
| Expression Level and Clinical Significance of IL-33 in Peripheral Bloodof Patients with Ankylosing Spondylitis |
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| DOI： |
| 中文关键词: 强直性脊柱炎 IL-33 红细胞沉降率 |
| 英文关键词: Ankylosing spondylitis IL-33 ESR |
| 基金项目:国家自然科学基金项目（81071454）；309医院重点课题（2013ZD-003） |
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| 中文摘要: |
| 目的：探讨IL-33在强直性脊柱炎（AS）患者外周血中的表达水平及临床意义。方法：选择我院2013年12月至2014 年8 月
收治的80 例AS 患者作为研究组，另选取同期在我院进行健康体检的80 例作为对照组。检测两组患者外周血中IL-33 的表达情
况，记录研究组患者病情活动指数（BASDAI）、红细胞沉降率（ESR）及C- 反应蛋白（CRP）水平，分析IL-33 表达水平与BASDAI、
ESR 及CRP 的相关性。结果：研究组患者血浆IL-33 水平明显高于对照组，差异具有统计学意义（t=6.15，P=0.025）。AS 患者外周
血IL-33 水平与BASDAI 和CRP 具有显著正相关关系（r=0.432, 0.525，P=0.034, 0.029)，而与ESR 无显著相关性（r=0.175，
P=0.214）。结论：AS患者外周血中IL-33 呈高表达，说明其可能参与AS的发生及发展。 |
| 英文摘要: |
| Objective:To investigate the expression level and clinical significance of IL-33 in peripheral blood of patients with
ankylosing spondylitis (AS).Methods:80 cases with AS in our hospital from December 2013 to August 2014 were selected as the study
group and another 80 healthy people were selected as the control group. Then the expression of IL-33 in peripheral blood plasma of
patients were detected and compared between the two groups, and the disease activity index (BASDAI), the erythrocyte sedimentation
rate (ESR) and the c-reactive protein (CRP) of the study group were analyzed.Results:IL-33 level of the study group was higher than that
of the control group with statistically significant differences (t=6.15, P=0.025). IL-33 level had a positive correlation with BASDAI and
CRP in AS patients (r=0.432, 0.525, P=0.034, 0.029), and no significant correlation with ESR (r=0.175, P=0.214).Conclusion:The
expression level of IL-33 in peripheral blood of AS patients increased significantly, which has an important significance for clinical
diagnosis. |
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