| 张少波 谢伟东 顾大勇 林裕龙 许乃寒 张雅鸥.microRNA作为传染性疾病标志物的研究进展[J].,2015,15(16):3158-3164 |
| microRNA作为传染性疾病标志物的研究进展 |
| MicroRNAs as Biomarkers of Infectious Diseases |
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| DOI： |
| 中文关键词: microRNA 传染性疾病 病毒 标志物 检测技术 |
| 英文关键词: MicroRNAs Infectious Diseases Virus Biomarkers Detection Technology |
| 基金项目:国家自然科学基金项目（81373460，81072680）；深圳市科技研发资金-深港协同创新资助（SGLH20121008144756945） |
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| 中文摘要: |
| 传染性疾病往往具有较大的传染性,易于大面积流行，且难以控制，严重危害人们生命健康，快速准确的筛查成为预防及控
制其传播的重要手段之一。MicroRNA(miRNA)是一类长度仅有约22nt的非编码单链微小RNA，广泛存在于动植物真核细胞中，
主要通过与靶mRNA分子的3' 端非编码区域(3'-untranslated region，3'UTR)完全或不完全互补配对，调控该mRNA分子的表达或
转录后翻译；在细胞生长、发育、凋亡，肿瘤形成，病毒感染等多种生理病理过程中起重要作用。在病毒感染时，miRNA 调控病毒与
宿主之间的相互作用，影响病毒感染的进程与结局；感兴趣的是，miRNA 其自身的表达对病毒感染具有一定的特异性。因此，
miRNA有望成为筛查病毒传染性疾病的临床标志物，目前已成为一热点研究领域。本文主要从循环体液中miRNA的稳定性，
miRNA在病毒感染中的特异性表达，以及miRNA检测技术方面做简要综述，并对miRNA作为传染病一种新型检测标志物的可
行性进行了初步的分析。 |
| 英文摘要: |
| Infectious diseases normally tend to have very strong infectivity, and be easy to widely spread in a large geographical
area and difficult to control. Therefore, they cause serious harm to people's life and health. Rapid and accurate screening has become the
urgent need for the prevention and control of their prevalence. MicroRNAs (miRNAs) are a class of small noncoding RNAs (about 22
nucleotides, nt ), commonly found in eukaryotic cells. MiRNAs play critical roles in a variety of physiological and pathological processes
including cell growth, development and apoptosis, tumorigenesis and virus infection by regulating gene expression or post-transcriptional
translation, which work by perfect or imperfect base pairing between short seed regions of miRNAs and 3' UTR of target mRNAs. During
virus infection, miRNAs are documented to have crucial impact on the interaction between viruses and hosts. Interestingly, the specific
expressions of miRNAs make them expected to become clinical markers for screening virus infectious diseases, which are emerging as a
hot research field. This paper summarizes the stability of miRNAs in human body fluids, reviews the specificity of miRNAs expression in
virus infection and the methods of miRNAs detection, and performs the feasibility analysis about miRNA as a group of novel and
potential biomarkers of virus-related infectious diseases. |
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