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目的：观察非小细胞肺癌中ERCC1 和RRM1 表达，并探讨其临床意义。方法：选择本院及西安交通大学第一附属胸外二科于2013 年1 月-2013 年6 月收治的经术后病理证实为非小细胞癌肺癌患者40 例作为研究对象，均采取免疫组化技术测定组织中ERCC1 和RRM1 表达水平，并分析ERCC1 和RRM1 表达水平与患者年龄、病理分期、是否淋巴结转移等相关因素之间的关系。结果：40 例非小细胞肺癌患者中，ERCC1表达阴性28 例（70.0 %），阳性12 例（30.0 %）；RRM1 表达阴性9 例（22.5 %），阳性 31 例（77.5 %）。ERCC1 和RRM1表达阴性非小细胞肺患者生存期均优于表达阳性患者，均P<0.05。患者非小细胞癌TNM分期及淋巴结转移转移情况与ERCC1 及RRM1 表达情况具有相关性，均P<0.05。结论：非小细胞肺癌ERCC1 和RRM1表达水平测定有助于预后情况，具有重要临床价值。

英文摘要:

Objective:To investigate the expression of ERCC1 and RRM1 in non small cell lung cancer, and to explore its clinical significance.Methods:40 patients were selected from the 2nd Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, who were confirmed non-small cell lung cancer. Then the levels of ERCC1 and RRM1 were detected by immunohistochemistry technology, and the relationship between ERCC1 and RRM1 expression, patient age, and disease stage were analyzed.Results:40 patients with non small cell lung cancer, the expression of ERCC1 was negative in 28 patients (70 %) and positive in 12 patients (30 %); the expression of RRM1 was negative in 9 cases (22.5 %) and positive in 34 patients (77.5 %). The survival time of patients with ERCC1 and RRM1 in negative expression was better than that of positive expression patients (P<0.05). ERCC1 and RRM1 expression in the patients with non small cell lung cancer had correlation with TNM staging and lymph node metastasis (P<0.05).Conclusion:The determination of ERCC1 and RRM1 expression in non small cell lung cancer is helpful for prognosis, so it has important clinical value.

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