| 陈宇丹 胡文立 袁俊亮 魏恒阳 孙毅娜.缺血性中风患者脑血管支架植入最佳时机的分析[J].,2015,15(15):2855-2858 |
| 缺血性中风患者脑血管支架植入最佳时机的分析 |
| Analysis of the Optimumtime of Cerebrovascular Stent Implantation forPatients with Ischemic Stroke |
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| DOI： |
| 中文关键词: 缺血性中风 支架植入 手术时机 神经细胞再生 |
| 英文关键词: Ischemic stroke Stent implantation Timing Nerve regeneration |
| 基金项目:国家重大科技研究专项（90706028） |
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| 中文摘要: |
| 目的：探讨缺血性中风患者脑血管支架植入的最佳时机。方法：选取我院收治的缺血性脑血管疾病患者90 例，依据发病时
间分为三组并进行脑血管支架植入术。对比三组患者治疗前后脑血管血流速度、认知功能评分及血管内皮细胞生长因子
（VEGE）、碱性成纤维细胞生长因子（bFGF）、神经生长因子（NGF）的含量变化。结果：①三组患者手术后的脑血管血流速度与手术
前相比明显改善，差异有统计学意义（P＜0.05），但三组之间比较无明显差异（P＞0.05）；②三组患者手术后的认知功能均较手术
前有所改善，与A 组和C 组比较，B 组认知功能评分明显升高，差异有统计学意义（P＜0.05），而A 组和C 组比较无明显差异
（P＞0.05）；③三组患者手术后的血清VEGE、bFGF、NGF含量均较手术前升高，且B 组明显高于A 组和C组，差异有统计学意义
（P＜0.05），而A 组和C 组间比较无明显差异（P＞0.05）。结论：脑血管支架植入时机与缺血性中风患者的临床疗效及预后可能有
一定相关性，发病后1 个月为脑血管支架植入最佳时机。 |
| 英文摘要: |
| Objective:To investigate the optimum time of cerebrovascular stent implantation for patients with ischemic stroke.Methods:90 patients with ischemic cerebrovascular disease admitted in our hospital were selected and divided into three groups according
to the time of operation and all the three groups were treated with the cerebrovascular stent implantation. Then the blood flowvelocity,
the cognitive function score, the levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and nerve
growth factor (NGF) were observed and compared before and after treatment between the three groups.Results:①The velocity of cerebral
blood flow after operation in the three groups all improved significantly with statistically differences compared with those before
treatment(P<0.05); there was no statistically significant difference within three groups (P>0.05). ②The cognitive function scores of three
groups all improved after treatment than those before treatment with statistically significant differences (P<0.05); the cognitive function
score of group B increased obviously than those of the other two groups (P<0.05); there was no statistically significant difference between
group A and groupC (P>0.05); ③The levels of VEGE, bFGF and NGF in the three groups after treatment were better than those before
treatment with statistically significant differences(P<0.05); the levels of VEGE, bFGF and NGF in group B increased obviously than those
of the other two groups (P<0.05); there was no statistically significant difference between group Aand group C(P>0.05).Conclusion:The
time of cerebrovascular stent implantation could have correlation with the regeneration of nerve cells in ischemic stroke patients, 1 month
after the onset of ischemic stroke could be the optimumtime of cerebrovascular stent implantation. |
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