| 徐舒曼 张幸平 甘露 李甲初 朱宇熹 赵斌 刘梅.重组人血管内皮抑素联合化放疗治疗晚期恶性肿瘤的临床观察[J].,2015,15(14):2685-2688 |
| 重组人血管内皮抑素联合化放疗治疗晚期恶性肿瘤的临床观察 |
| Clinical Observation of Recombinant Human Endostatin Combined withChemoradiotherapy for Advanced Malignancies |
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| DOI： |
| 中文关键词: 重组人血管内皮抑素 抗血管生成治疗 恶性肿瘤 化疗 放疗 |
| 英文关键词: Recombinant human endostatin(rh-ES) Antiangiogenesis therapy Malignancies Chemotherapy Radiotherapy |
| 基金项目:国家临床重点专科建设项目经费资助（国卫办医函[2013]544 号） |
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| 中文摘要: |
| 目的：探讨重组人血管内皮抑素（recombinant human endostatin，rh-ES）联合化放疗治疗晚期恶性肿瘤的疗效及安全性。方
法：回顾性分析我科2010 年1 月至2013 年8 月收治的27 例晚期恶性肿瘤患者病例，27 例患者均接受rh-ES 联合化疗± 放疗的
综合治疗，rh-ES 用药1 周期后评价生活质量变化及不良反应，2 周期后评价疗效。结果：23 例可评价近期疗效的患者客观有效率
30.4%，疾病控制率78.3%。18 例非小细胞肺癌（non-small cell lung cancer，NSCLC）中位无进展生存期5.5 月，中位总生存期12.0
月，1 年生存率50.0%，2 年生存率28.6%。全组患者生活质量改善或稳定23 例（85.2%），Ⅲ～Ⅳ度不良反应8 例次。结论：Rh-ES
联合化放疗治疗晚期恶性肿瘤的疗效及安全性良好，可改善或稳定患者生活质量。与其他单纯化疗研究结果比较，晚期NSCLC
的中位无进展生存期及1 年生存率较高，值得临床推广。 |
| 英文摘要: |
| Objective:To investigate the efficacy and safety of recombinant human endostatin (rh-ES) combined with
chemotherapy (CT) or chemoradiotherapy (CRT) in treatment of advanced malignancies.Methods:27 cases of advanced malignancies in
our department fromJanuary 2010 to August 2013 were retrospectively analyzed. All 27 patients were treated with Rh-ES combined with
CT or CRT. The safety and changes of the quality of life were evaluated after one cycle after treatment,and the efficacy was evaluated
after two cycles.Results:Among 23 evaluable cases, the objective response rate (ORR) was 30.4% and the disease control rate (DCR)
was 78.3%. Among 18 cases of advanced non-small cell lung cancer (NSCLC), the median progression free survival (PFS) was 5.5
months, and the median overall survival (OS) was 12.0 months,1-year survival rate was 50.0%, and 2-year survival rate was 28.6%. For
the quality of life (QOL) of these patients, 23 cases (85.2%) were improved or stable. The adverse reaction of G3/4 was present only 8
times.Conclusion:Rh-ES combined CT or CRT were effective and safety for advanced malignancies, and the quality of life could be
improved or remained stable. Compared with other results of chemotherapy alone, the median PFS and 1-year survival rate in advanced
NSCLC were higher, so it is worthy for further clinical application. |
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