| 张佳斌 任辉 纪旭 冯学会 李丽昕 于德磊 王洪波 刘振文.TGF-beta1表达水平与原发性肝癌浸润及转移的关系[J].,2015,15(14):2666-2669 |
| TGF-beta1表达水平与原发性肝癌浸润及转移的关系 |
| Research on Relationship of TGF beta-1 Expression and Metastasis ofPrimary Liver Cancer |
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| DOI： |
| 中文关键词: 转化生长因子beta1 原发性肝癌 侵袭 转移 |
| 英文关键词: TGF-beta1 Primary liver cancer Infiltration Metastasis |
| 基金项目:解放军302 医院院长创新课题《利用计算机辅助技术建立基于肝癌总体积的新型肝移植患者入选标准》（YNKT2013020） |
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| 中文摘要: |
| 目的：探讨转化生长因子beta1（TGF-beta1）在原发性肝癌组织中的表达及其与肿瘤侵袭和转移的关系。方法：选择288 例确诊为
原发性肝癌患者作为研究组，另选取274 例健康志愿者作为对照组。应用酶联免疫吸附法检测两组研究对象血清TGF-beta1 水平，
免疫组织化学标记法检测肝癌患者肿瘤组织、癌旁组织及正常肝脏组织中TGF-beta1 的表达情况，并结合临床病理资料进行相关性
分析。结果：原发性肝癌患者血清中TGF-茁1 水平明显高于对照组，差异具有统计学意义（P <0.01）。血清TGF-beta1 水平与肿瘤的组
织学分级、浸润深度及转移呈正相关（P <0.01）。肝癌患者肿瘤组织中TGF-beta1 表达水平明显高于正常肝脏组织及癌旁组织，差异
具有统计学意义（P <0.01）。结论：血清TGF-beta1与原发性肝癌的侵袭和转移密切相关。TGF-beta1 可能会改变肿瘤微环境，增加侵袭
和转移的潜力。 |
| 英文摘要: |
| Objective:To study the expression of TGF-beta1 in primary liver cancer and the relationship with the invasion and
metastasis for tumor.Methods:Serum levels of TGF-beta1 of 288 cancer patients and 274 healthy volunteers were detected by means of
enzyme-linked immunosorbent assay. Expression of TGF-beta1 in liver cancer tissue was detected through the method of
immunohistochemical markers, so as to analyze its relationship with clinical pathology of primary liver cancer.Results:TGF-beta1 in the
serumof patients with primary liver cancer was significantly higher than that in healthy control group (P<0.01). Elevated serumlevels of
TGF-beta1 were closely related to level of histological grade, infiltration depth, and metastasis of tumor (P<0.01). TGF-beta1 expression level
in 288 cases of hepatocellular carcinoma was significantly higher than that in the normal liver tissue and cancer adjacent tissues (P<0.01).Conclusion:The serum level of TGF-茁1 was closely related to invasion and metastasis of primary liver cancer. TGF-beta1 is likely to
change the tumor microenvironment, and increase the potential of tumor invasion and metastasis. Serum levels of TGF-beta1 expression
level can be considered as a biological behavior and prognosis of primary liver cancer. |
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