| 李晓伟 许冰 刘剑 殷继鹏 尚鑫 夏丽敏 吴开春△.JMJD6在胃癌组织中的表达及意义[J].,2015,15(14):2621-2624 |
| JMJD6在胃癌组织中的表达及意义 |
| Expression and Significance of JMJD6 in the Gastric Cancer |
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| DOI： |
| 中文关键词: JMJD6 蛋白 胃癌 表达 临床病理特征 |
| 英文关键词: JMJD6 Gastric Cancer Expression Clinicopathological characteristics |
| 基金项目:国家973项目（2010CB529302）；国家自然科学基金项目（81272652，81172290，91129723） |
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| 中文摘要: |
| 目的：检测JMJD6蛋白在胃癌组织及相应癌旁正常组织中的表达情况，并分析JMJD6 蛋白表达与胃癌患者临床病理参数
及预后的关系。方法：应用免疫组织化学方法检测JMJD6 蛋白在胃癌组织及相应癌旁正常组织中的表达情况，进一步用
Kaplan-Meier 生存分析、COX比例风险回归模型等统计学方法研究JMJD6 表达与胃癌患者临床病理参数及预后的关系。结果：
JMJD6 在胃癌组织中的表达阳性率显著高于癌旁正常组织(P=0.001)；JMJD6 在胃癌组织的高表达与肿瘤临床分期(P=0.008)、病
理分级(P=0.001)、局部浸润深度(P=0.028)、有无淋巴结转移(P=0.001)等显著相关；Kaplan-Meier 生存分析结果表明JMJD6 高表达
的胃癌患者术后总体生存率显著低于JMJD6 低表达的患者(P=0.023)。结论：JMJD6 在胃癌的发生发展中可能发挥了癌基因样作
用，可能作为胃癌治疗的潜在靶点。 |
| 英文摘要: |
| Objective:To detect the expression of Jumonji domain containing 6 (JMJD6) in gastric cancer (GC) tissues and
adjacent non-tumor tissues, and investigate the significance of JMJD6 in GC.Methods:JMJD6 expression in 90 pairs of GC tissues and
corresponding non-tumor tissues was detected by immunohistochemistry. The correlation of JMJD6 expression with the
clinicopathological characteristics of GC was analyzed by Kaplan-Meier and Cox regression.Results:The expressions of JMJD6 protein
in GC tissues was significantly higher than that in adjacent non-tumor tissues (P=0.001). Further analysis showed that the high expression
of JMJD6 protein in GC tissues was significantly related to the clinical stage (P=0.008), Pathological grade (P=0.001), tumor local
invasion depth (P=0.028), tumor-node-metastasis stage (P=0.001). Kaplan-Meier survival analysis showed that GC patients with a higher
expression of JMJD6 had a poorer prognosis (P=0.023).Conclusion:JMJD6 may act as an oncogene in the initiation and progression of
GC; JMJD6 might be a potential therapeutic target of GC. |
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