| 侯国伟 刘晓菲 王环 王宁 张哲男 赵志威 朴大勋△.DC-CIK治疗大肠癌的研究进展[J].,2015,15(13):2574-2576 |
| DC-CIK治疗大肠癌的研究进展 |
| Research Progress on the DC-CIK in the Treatment of Colorectal Cancer |
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| DOI： |
| 中文关键词: 树突状细胞 细胞因子诱导的杀伤细胞 大肠癌 治疗 研究进展 |
| 英文关键词: DC CIK Colorectal cancer Treatment Research progress |
| 基金项目:吴阶平医学基金会临床科研专项基金（320.6750.12172） |
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| 中文摘要: |
| 大肠癌是消化道常见的恶性肿瘤之一，发病率和死亡率均较高。过继免疫治疗是当今肿瘤治疗的热点，已逐步成为一些肿
瘤的首选治疗方法。树突状细胞(DC)是目前已知功能最强大的抗原呈递细胞，具有呈递肿瘤抗原和抵制肿瘤细胞免疫逃逸及刺
激T淋巴细胞产生免疫应答的作用。细胞因子诱导的杀伤细胞(CIK)由多种细胞因子诱导而成，具有T淋巴细胞及NK细胞抗肿
瘤作用的特点。DC和CIK 细胞有效结合可以同时促进DC 细胞的增殖和免疫功能及加强CIK 细胞的抗肿瘤作用。本文就近年来
国内外应用DC-CIK 治疗大肠癌的研究进展进行综述。 |
| 英文摘要: |
| Colorectal cancer is the most common digestive systerm malignant tumor in the world, which has high morbidity and
mortality. Adoptive immunity therapy of tumor is the hot pints in tumor treatment nowdays, It has been the prime choice of treament in
some cancer step by step. Dendritic cells (DC) is known as the most powerful antigen-presenting cells at present. It has the function of
rendering tumor antigens and resistancing the immune escape of tumor cells and stimulating T lymphocytes to produce immune response.
Cytokine induced killer cells (CIK) is induced by a variety of cytokines, It has the characteristics of antitumor effect of T lymphocyte and
NK cell. The effective combination of DC and CIK cells can promote DC cells proliferation and immune function and strengthen the antitumor
effect of CIK cells at the same time. This article will summariz the research progress of application of DC-CIK in the treatment of
colorectal cancer. |
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