| 洪杏芳 申元英.循环miRNAs在几种肝病检测中的研究进展[J].,2015,15(12):2366-2369 |
| 循环miRNAs在几种肝病检测中的研究进展 |
| Progress of Circulating MicroRNAs in the Detection of Liver Diseases |
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| DOI： |
| 中文关键词: miRNAs 肝脏疾病 生物标记物 临床应用 |
| 英文关键词: miRNAs Liver diseases Biomarker Clinical application |
| 基金项目:云南省高等学校名师工作室（2012038）；云南省十二五优势特色重点学科项目（2011030） |
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| 中文摘要: |
| microRNAs（miRNAs）是一类单链非编码的内源性小RNA分子，参与细胞、组织甚至个体的生长发育。以往人们主要研究的
是肝脏组织中miRNAs在肝脏相关疾病检测中的应用，随着2008 年血液中miRNAs 的发现，循环miRNAs 在疾病检测中的研究
逐渐成为热点。microRNAs普遍存在于血液中，与肝癌、肝硬化等多种肝脏疾病的发生发展密切相关。本文介绍了循环miRNAs
的来源及其特异性、稳定性等特性，简述了循环miRNAs传统和最新的检测方法及特点，总结了循环miRNAs在肝癌、肝炎、肝硬
化、药物性肝损伤等肝脏疾病检测中的研究进展。近年研究表明循环miRNAs检测具有采样方便、稳定性好、灵敏度高、可连续监
测等优势，在肝脏相关疾病的诊断和预测中发挥了越来越重要的作用，其临床意义及应用前景已引起高度关注。本文重点综述在
前人的研究结果中有望成为肝脏相关疾病诊断和预后判断的循环miRNAs 分子标志物发现目前的很多研究只是停留在实验室
阶段，尚缺乏简单有效的诊断方法和统一的诊断标准，未来研究的热点应集中在如何进一步提高有潜力的miRNAs 分子标志物
的敏感性、特异性和标准化，使其真正应用于临床诊断。 |
| 英文摘要: |
| MicroRNAs (miRNAs) are a class of small, single stranded, and non-coding endogenous RNAs, which not only affect
the growth and development of organisms, but also participate in many diseases progresses. In the past, the study of liver tissue's
MicroRNAs in the Detection of Liver Diseases is the major trend, with the discovery of miRNAs in blood at 2008, circulating miRNAs in
disease detection has been a hot spot. MicroRNAs are widespread in the bloodstream and are closely related with liver cancer, liver
cirrhosis and other liver disease. miRNAs surviving fromendogenous RNase are stable and abundant in plasma, which indicates that they
probably play an important role in tumor diagnosis. The title briefly introduces traditional and the latest detection methods and
summarizes the advanced development in liver fibrosis, viral hepatitis, and hepatocellular carcinoma ( HCC). In recent years, studies have
shown that circulating miRNAs detection has good stability, high sensitivity, and can be continuously monitored and other advantages.
More and more attentions are paid to the clinical significance and application for specific miRNA detection and forcast in liver diseases
so far. This article focuses on the circulating miRNAs which are expected to become the diagnostic and prognostic molecular markers.
We discovered that many of the current study was only in the laboratory stage and was lack of simple and effective diagnostic methods
and uniform diagnostic criteria. So the future research should focus on improving the sensitivity, specificity and standardization of the
promising circulating miRNAs, making it really used in the clinical diagnosis. |
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