| 盛婷 傅念 阳学风 吴青 刘瑛.肝纤维化发病机制中细胞和分子机制的研究进展[J].,2015,15(12):2358-2362 |
| 肝纤维化发病机制中细胞和分子机制的研究进展 |
| Mechanisms of Cellular and Molecular in the Pathogenesis of Liver Fibrosis |
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| DOI： |
| 中文关键词: 肝脏 肝纤维化 肝硬化 肝星状细胞（HSC） 细胞外基质 |
| 英文关键词: Liver Liver fibrosis Cirrhosis Hepatic stellate cells Extracellular matrix |
| 基金项目:国家自然科学基金项目（81373465） |
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| 中文摘要: |
| 关于肝纤维化形成的复杂的细胞和分子联系已经有了相当多的研究进展。最近的数据表明，纤维化进程的终止和纤维分解
途径的恢复可以逆转晚期肝纤维化甚至肝硬化。因此，需要更好地阐明参与肝纤维化的细胞和分子机制。HSC（肝星状细胞）的激
活是肝纤维化发生的中心事件，此外还有产生基质的其他细胞来源，包括肝门区的成纤维细胞，纤维细胞和骨髓来源的肌纤维母
细胞。这些细胞与其邻近细胞通过多种联系聚集产生纤维疤痕并造成持续性损伤。阐明不同类型的细胞的相互作用，揭示细胞因
子对这些细胞的影响，理清活化HSC 基因表达的调控，将有助于我们探索新的肝纤维化治疗靶点。此外，不同的病因有不同的致
病途径，弄清这一点有助于针对特异性疾病治疗方法的发现。本文概述了肝纤维化的细胞和分子机制的最新研究进展，可能为未
来治疗方法带来新的突破。 |
| 英文摘要: |
| There have been quite a lot of research progress complex cellular and molecular link on liver fibrosis .Recent data
indicate that the recovery process is terminated of fibrogenic processes and fiber decomposition pathways may allow the reversal of
advanced fibrosis and even cirrhosis. Therefore, efforts have been made to better elucidate the cellular and molecular mechanisms are
involved in liver fibrosis. Activation of hepatic stellate cells (HSC) remains a central event in fibrosis, complemented by other sources of
matrix-producing cells, including portal fibroblasts, fibrocytes and bone marrow-derived myofibroblasts. These cells converge in a
complex interaction with neighboring cells to provoke scarring in response to persistent injury. Defining the interaction of different cell
types, revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in
activated HSCs will enable the discovery of new therapeutic targets. Moreover, the characterization of different pathways associated with
different etiologies aid in the development of disease-specific therapies. This article outlines recent advances regarding the cellular and
molecular mechanisms involved in liver fibrosis that may be translated into future therapies. The pathogenesis of liver fibrosis associated
with alcoholic liver disease, non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms
involved in liver fibrosis. |
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